1N20

(+)-Bornyl Diphosphate Synthase: Complex with Mg and 3-aza-2,3-dihydrogeranyl diphosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n20a1	All alpha proteins	alpha/alpha toroid	Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclase N-terminal domain	(+)-bornyl diphosphate synthase	garden sage (Salvia officinalis ) [TaxId: 38868 ],	SCOPe (2.08)
A	d1n20a2	All alpha proteins	Terpenoid synthases	Terpenoid synthases	Terpenoid cyclase C-terminal domain	(+)-bornyl diphosphate synthase	garden sage (Salvia officinalis ) [TaxId: 38868 ],	SCOPe (2.08)
B	d1n20b1	All alpha proteins	alpha/alpha toroid	Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclase N-terminal domain	(+)-bornyl diphosphate synthase	garden sage (Salvia officinalis ) [TaxId: 38868 ],	SCOPe (2.08)
B	d1n20b2	All alpha proteins	Terpenoid synthases	Terpenoid synthases	Terpenoid cyclase C-terminal domain	(+)-bornyl diphosphate synthase	garden sage (Salvia officinalis ) [TaxId: 38868 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Terpenoid cyclases/Protein prenyltransferases	8043990	3001024	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Terpenoid synthases	8043991	3001615	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Terpenoid synthases	8043991	3001615	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Terpenoid cyclases/Protein prenyltransferases	8043990	3001024	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Terpene_synth_C	e1n20A1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: Terpene_synth_C	ECOD (1.6)
A	Terpene_synth	e1n20A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Terpene_synth	ECOD (1.6)
B	Terpene_synth_C	e1n20B1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: Terpene_synth_C	ECOD (1.6)
B	Terpene_synth	e1n20B2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Terpene_synth	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.50.10.130	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase	Terpene synthase, N-terminal domain	CATH (4.3.0)
A	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
B	1.50.10.130	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase	Terpene synthase, N-terminal domain	CATH (4.3.0)
B	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03936	Terpene synthase family, metal binding domain (Terpene_synth_C)	Terpene synthase family, metal binding domain	It has been suggested that this gene family be designated tps (for terpene synthase) [1]. It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synt ...	It has been suggested that this gene family be designated tps (for terpene synthase) [1]. It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.	Domain
A, B	PF01397	Terpene synthase, N-terminal domain (Terpene_synth)	Terpene synthase, N-terminal domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	(+)-bornyl diphosphate synthase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding intramolecular lyase activity isomerase activity geranyl-diphosphate cyclase activity cyclase activity catalytic activity identical protein binding protein binding protein homodimerization activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding intramolecular lyase activity isomerase activity geranyl-diphosphate cyclase activity cyclase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity camphene synthase activity carbon-oxygen lyase activity, acting on phosphates lyase activity carbon-oxygen lyase activity terpene synthase activity	diterpenoid metabolic process isoprenoid biosynthetic process cellular biosynthetic process cellular metabolic process lipid biosynthetic process primary metabolic process terpenoid biosynthetic process diterpenoid biosynthetic process biosynthetic process cellular lipid metabolic process metabolic process cellular process terpenoid metabolic process isoprenoid metabolic process diterpenoid metabolic process isoprenoid biosynthetic process cellular biosynthetic process cellular metabolic process lipid biosynthetic process primary metabolic process terpenoid biosynthetic process diterpenoid biosynthetic process biosynthetic process cellular lipid metabolic process metabolic process cellular process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process small molecule biosynthetic process monoterpenoid metabolic process monoterpenoid biosynthetic process cellular ketone metabolic process (+)-camphor biosynthetic process small molecule metabolic process (+)-camphor metabolic process ketone biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure plastid organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle chloroplast

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005630	Terpene synthase, metal-binding domain	Domain
A, B	IPR008949	Isoprenoid synthase domain superfamily	Homologous Superfamily
A, B	IPR036965	Terpene synthase, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR044814	Terpene cyclases, class 1, plant	Family
A, B	IPR001906	Terpene synthase, N-terminal domain	Domain
A, B	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	bornyl diphosphate synthase M-CSA #259	Boronyl diphosphate synthase catalyses the conversion of geranyl diphosphate to boronyl diphosphate. It is a member of the monoterpene synthases, a group of enzymes that catalyse the metal-dependent cyclisation of geranyl diphosphate to a variety of monoterpene products via carbocation intermediates.	Defined by 9 residues: TRP:A-274 [auth A-323]ILE:A-295 [auth A-344]ASP:A-302 [auth A-351]ASP:A-306 [auth A-355]VAL:A-403 [auth A-452]ASP:A-447 [auth A-496]THR:A-451 [auth A-500]GLU:A-455 [auth A-504]PHE:A-529 [auth A-578] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 5.5.1.8 (PDB Primary Data) Search M-CSA Motif + EC 5.5.1.8 EC: 4.2.3.116 (UniProt) Search M-CSA Motif + EC 4.2.3.116 EC: 4.2.3.121 (UniProt) Search M-CSA Motif + EC 4.2.3.121

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.