1N6E

tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n6ea1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6ea2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6ea3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6ea4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tricorn_PDZ	e1n6eA2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
A	DPPIV_N_1	e1n6eA4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
A	DPPIV_N	e1n6eA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
A	Tricorn_C1	e1n6eA5	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
A	Peptidase_S41	e1n6eA1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
C	Tricorn_PDZ	e1n6eC4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
C	DPPIV_N_1	e1n6eC5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
C	DPPIV_N	e1n6eC2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
C	Tricorn_C1	e1n6eC1	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
C	Peptidase_S41	e1n6eC3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
E	Tricorn_PDZ	e1n6eE1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
E	DPPIV_N_1	e1n6eE5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
E	DPPIV_N	e1n6eE4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
E	Tricorn_C1	e1n6eE3	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
E	Peptidase_S41	e1n6eE2	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
G	Tricorn_PDZ	e1n6eG5	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
G	DPPIV_N_1	e1n6eG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
G	DPPIV_N	e1n6eG4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
G	Tricorn_C1	e1n6eG2	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
G	Peptidase_S41	e1n6eG3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
I	Tricorn_PDZ	e1n6eI4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
I	DPPIV_N_1	e1n6eI1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
I	DPPIV_N	e1n6eI5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
I	Tricorn_C1	e1n6eI3	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
I	Peptidase_S41	e1n6eI2	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
K	Tricorn_PDZ	e1n6eK3	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
K	DPPIV_N_1	e1n6eK4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
K	DPPIV_N	e1n6eK5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
K	Tricorn_C1	e1n6eK2	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
K	Peptidase_S41	e1n6eK1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
A	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
C	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
E	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
E	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
E	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
E	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
G	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
G	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
G	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
G	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
I	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
I	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
I	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
I	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
I	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
K	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
K	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
K	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
K	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
K	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K	PF03572	Peptidase family S41 (Peptidase_S41)	Peptidase family S41	-	Family
A, C, E, G, I A, C, E, G, I, K	PF14684	Tricorn protease C1 domain (Tricorn_C1)	Tricorn protease C1 domain	This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain [1].	Domain
A, C, E, G, I A, C, E, G, I, K	PF14685	Tricorn protease PDZ domain (Tricorn_PDZ)	Tricorn protease PDZ domain	This domain is the PDZ domain of tricorn protease [1].	Domain
A, C, E, G, I A, C, E, G, I, K	PF07676	WD40-like Beta Propeller Repeat (PD40)	WD40-like Beta Propeller Repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K	Tricorn protease	peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm
B, D, F, H, J B, D, F, H, J, L	DQTQKAAAELTFF	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K	IPR005151	Tail specific protease	Domain
A, C, E, G, I A, C, E, G, I, K	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR011659	WD40-like beta propeller	Repeat
A, C, E, G, I A, C, E, G, I, K	IPR028204	Tricorn protease C1 domain	Domain
A, C, E, G, I A, C, E, G, I, K	IPR029414	Tricorn protease, PDZ domain	Domain
A, C, E, G, I A, C, E, G, I, K	IPR012393	Tricorn protease	Family
A, C, E, G, I A, C, E, G, I, K	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR036034	PDZ superfamily	Homologous Superfamily