1N6F

tricorn protease in complex with Z-Phe-diketo-Arg-Glu-Phe

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n6fa1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6fa2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6fa3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6fa4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
B	d1n6fb1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
B	d1n6fb2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
B	d1n6fb3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
B	d1n6fb4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6fc1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6fc2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6fc3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6fc4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
D	d1n6fd1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
D	d1n6fd2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
D	d1n6fd3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
D	d1n6fd4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6fe1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6fe2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6fe3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6fe4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
F	d1n6ff1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
F	d1n6ff2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
F	d1n6ff3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
F	d1n6ff4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tricorn_PDZ	e1n6fA4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
A	DPPIV_N_1	e1n6fA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
A	DPPIV_N	e1n6fA5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
A	Tricorn_C1	e1n6fA2	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
A	Peptidase_S41	e1n6fA1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
B	Tricorn_PDZ	e1n6fB3	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
B	DPPIV_N_1	e1n6fB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
B	DPPIV_N	e1n6fB4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
B	Tricorn_C1	e1n6fB1	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
B	Peptidase_S41	e1n6fB5	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
C	Tricorn_PDZ	e1n6fC4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
C	DPPIV_N_1	e1n6fC5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
C	DPPIV_N	e1n6fC3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
C	Tricorn_C1	e1n6fC2	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
C	Peptidase_S41	e1n6fC1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
D	Tricorn_PDZ	e1n6fD5	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
D	DPPIV_N_1	e1n6fD4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
D	DPPIV_N	e1n6fD2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
D	Tricorn_C1	e1n6fD3	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
D	Peptidase_S41	e1n6fD1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
E	Tricorn_PDZ	e1n6fE5	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
E	DPPIV_N_1	e1n6fE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
E	DPPIV_N	e1n6fE2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
E	Tricorn_C1	e1n6fE4	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
E	Peptidase_S41	e1n6fE3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
F	Tricorn_PDZ	e1n6fF4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
F	DPPIV_N_1	e1n6fF2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
F	DPPIV_N	e1n6fF5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
F	Tricorn_C1	e1n6fF3	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
F	Peptidase_S41	e1n6fF1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
A	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
B	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
C	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
D	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
D	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
D	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
D	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
E	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
E	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
E	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
E	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
F	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
F	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
F	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
F	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
F	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF03572	Peptidase family S41 (Peptidase_S41)	Peptidase family S41	-	Family
A, B, C, D, E A, B, C, D, E, F	PF14684	Tricorn protease C1 domain (Tricorn_C1)	Tricorn protease C1 domain	This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF14685	Tricorn protease PDZ domain (Tricorn_PDZ)	Tricorn protease PDZ domain	This domain is the PDZ domain of tricorn protease [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF07676	WD40-like Beta Propeller Repeat (PD40)	WD40-like Beta Propeller Repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	tricorn protease	peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR005151	Tail specific protease	Domain
A, B, C, D, E A, B, C, D, E, F	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR011659	WD40-like beta propeller	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR028204	Tricorn protease C1 domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR029414	Tricorn protease, PDZ domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR012393	Tricorn protease	Family
A, B, C, D, E A, B, C, D, E, F	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036034	PDZ superfamily	Homologous Superfamily