1NEK

Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1neka1	All alpha proteins	Spectrin repeat-like	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	Succinate dehydogenase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1neka2	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	Succinate dehydogenase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1neka3	Alpha and beta proteins (a+b)	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydogenase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1nekb1	All alpha proteins	Globin-like	alpha-helical ferredoxin	Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain	Succinate dehydogenase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1nekb2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	Succinate dehydogenase iron-sulfur protein, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1nekc_	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Fumarate reductase respiratory complex transmembrane subunits	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	Succinate dehydrogenase subunit SdhC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1nekd_	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Fumarate reductase respiratory complex transmembrane subunits	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	Succinate dehydrogenase subunit SdhD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	L-aspartate oxidase-like	8056066	4000053	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Succinate dehydrogenase/fumarate reductase domain-like	8056067	3000054	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L-aspartate oxidase C-terminal domain-like	8056068	3000021	SCOP2 (2022-06-29)
B	SCOP2 Family	Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain-like	8003627	4000221	SCOP2 (2022-06-29)
B	SCOP2 Family	2Fe-2S ferredoxin domains from multidomain proteins	8003628	4000241	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	alpha-helical ferredoxin	8017662	3000026	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	2Fe-2S ferredoxin-like	8017659	3000113	SCOP2 (2022-06-29)
C	SCOP2 Family	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	8031387	4001916	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Fumarate reductase respiratory complex transmembrane subunits	8043765	3000518	SCOP2 (2022-06-29)
D	SCOP2 Family	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	8031390	4001916	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Fumarate reductase respiratory complex transmembrane subunits	8043768	3000518	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Succ_DH_flav_C	e1nekA1	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: Succ_DH_flav_C	ECOD (1.6)
A	FAD_binding_2	e1nekA2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: FAD_binding_2	ECOD (1.6)
A	FAD_binding_3_1st	e1nekA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: FAD_binding_3_1st	ECOD (1.6)
B	Fer4_8	e1nekB1	A: alpha arrays	X: alpha-helical ferredoxin-like	H: alpha-helical ferredoxin (From Topology)	T: alpha-helical ferredoxin	F: Fer4_8	ECOD (1.6)
B	Fer2_3	e1nekB2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)
C	Sdh_cyt	e1nekC1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: Sdh_cyt	ECOD (1.6)
D	Sdh_cyt	e1nekD1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: Sdh_cyt	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
A	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
A	1.20.58.100	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	4.10.80.40	Few Secondary Structures	Irregular	Rhinovirus 14, subunit 4	succinate dehydrogenase protein domain	CATH (4.3.0)
B	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
B	1.10.1060.10	Mainly Alpha	Orthogonal Bundle	Fumarate Reductase Iron-sulfur Protein	Chain B, domain 2	CATH (4.3.0)
C	1.20.1300.10	Mainly Alpha	Up-down Bundle	3 helical TM bundles of succinate and fumarate reductases	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	CATH (4.3.0)
D	1.20.1300.10	Mainly Alpha	Up-down Bundle	3 helical TM bundles of succinate and fumarate reductases	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02910	Fumarate reductase flavoprotein C-term (Succ_DH_flav_C)	Fumarate reductase flavoprotein C-term	This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.	Domain
A	PF00890	FAD binding domain (FAD_binding_2)	FAD binding domain	-	Family
B	PF13085	2Fe-2S iron-sulfur cluster binding domain (Fer2_3)	2Fe-2S iron-sulfur cluster binding domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	Domain
B	PF13534	4Fe-4S dicluster domain (Fer4_17)	4Fe-4S dicluster domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	Domain
C	PF01127	Succinate dehydrogenase/Fumarate reductase transmembrane subunit (Sdh_cyt)	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Succinate dehydrogenase flavoprotein subunit	oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor succinate dehydrogenase (quinone) activity electron transfer activity	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy aerobic electron transport chain oxidative phosphorylation respiratory electron transport chain electron transport chain anaerobic respiration	cellular anatomical structure membrane cell periphery plasma membrane
B	Succinate dehydrogenase iron-sulfur protein	iron-sulfur cluster binding binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity 4 iron, 4 sulfur cluster binding electron transfer activity iron-sulfur cluster binding binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity 4 iron, 4 sulfur cluster binding electron transfer activity cation binding ion binding metal ion binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy aerobic electron transport chain oxidative phosphorylation respiratory electron transport chain electron transport chain	cellular anatomical structure membrane cell periphery plasma membrane
C	Succinate dehydrogenase cytochrome b-556 subunit	binding organic cyclic compound binding tetrapyrrole binding heme binding quinone binding ubiquinone binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity electron transfer activity binding organic cyclic compound binding tetrapyrrole binding heme binding quinone binding ubiquinone binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity electron transfer activity cation binding ion binding metal ion binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy aerobic electron transport chain oxidative phosphorylation respiratory electron transport chain electron transport chain cytochrome complex assembly cellular component organization aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy aerobic electron transport chain oxidative phosphorylation respiratory electron transport chain electron transport chain cytochrome complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	cellular anatomical structure membrane cell periphery plasma membrane
D	Succinate dehydrogenase hydrophobic membrane anchor protein	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy aerobic electron transport chain oxidative phosphorylation respiratory electron transport chain electron transport chain cytochrome complex assembly cellular component organization aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy aerobic electron transport chain oxidative phosphorylation respiratory electron transport chain electron transport chain cytochrome complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	cellular anatomical structure membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal	Domain
A	IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site	Binding Site
A	IPR037099	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily	Homologous Superfamily
A	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR003953	FAD-dependent oxidoreductase 2, FAD binding domain	Domain
A	IPR030664	FAD-dependent oxidoreductase SdhA/FrdA/AprA	Family
A	IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily	Homologous Superfamily
A	IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	Family
A	IPR011281	Succinate dehydrogenase, flavoprotein subunit	Family
B	IPR025192	Succinate dehydogenase/fumarate reductase N-terminal	Domain
B	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
B	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
B	IPR004489	Succinate dehydrogenase/fumarate reductase iron-sulphur protein	Family
B	IPR009051	Alpha-helical ferredoxin	Homologous Superfamily
B	IPR050573	Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur	Family
B	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
B	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
B	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
C	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
C	IPR014314	Succinate dehydrogenase, cytochrome b556 subunit	Family
C	IPR018495	Succinate dehydrogenase, cytochrome b subunit, conserved site	Conserved Site
C	IPR000701	Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit	Family
D	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
D	IPR000701	Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit	Family
D	IPR014312	Succinate dehydrogenase, hydrophobic membrane anchor	Family