1NQL

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)
BSCOP2 FamilyEGF-type module 8021128 4003198 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyEGF/Laminin-like 8033508 3000412 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARecep_L_domaine1nqlA1 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
AGF_recep_IVe1nqlA4 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: GF_recep_IVECOD (1.6)
AFurin-likee1nqlA3 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: Furin-likeECOD (1.6)
BEGFe1nqlB1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: EGFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a' Chain ACATH (4.3.0)
A2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1 Chain A domain 2CATH (4.3.0)
B2.10.25.10 Mainly Beta Ribbon Laminin LamininCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00757Furin-like cysteine rich region (Furin-like)Furin-like cysteine rich region- Domain
PF01030Receptor L domain (Recep_L_domain)Receptor L domain- Repeat
PF14843Growth factor receptor domain IV (GF_recep_IV)Growth factor receptor domain IVThis is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].Domain
PF00008EGF-like domain (EGF)EGF-like domainThere is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ...There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
epidermal growth factor receptor
epidermal growth factor

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP00533
PharosP01133