1NQL
Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1nqla1 | Alpha and beta proteins (a/b) | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | L domain-like | L domain | EGF receptor extracellular domain | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d1nqla3 | Small proteins | Knottins (small inhibitors, toxins, lectins) | Growth factor receptor domain | Growth factor receptor domain | EGF receptor Cys-rich domains, N-terminal domain | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d1nqla5 | Artifacts | Tags | Tags | Tags | N-terminal Tags | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d1nqlb_ | Small proteins | Knottins (small inhibitors, toxins, lectins) | EGF/Laminin | EGF-type module | Epidermal growth factor, EGF | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Growth factor receptor domain-like | 8038763 | 3000398 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | L domain-like | 8038760 | 3001010 | SCOP2B (2022-06-29) |
B | SCOP2 Family | EGF-type module | 8021128 | 4003198 | SCOP2 (2022-06-29) |
B | SCOP2 Superfamily | EGF/Laminin-like | 8033508 | 3000412 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Recep_L_domain | e1nqlA1 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: Recep_L_domain | ECOD (1.6) |
A | GF_recep_IV | e1nqlA4 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: GF_recep_IV | ECOD (1.6) |
A | Furin-like | e1nqlA3 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: Furin-like | ECOD (1.6) |
B | EGF | e1nqlB1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: EGF | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.80.20.20 | Alpha Beta | Alpha-Beta Horseshoe | 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a' | Chain A | CATH (4.3.0) |
A | 2.10.220.10 | Mainly Beta | Ribbon | Hormone Receptor, Insulin-like Growth Factor Receptor 1 | Chain A domain 2 | CATH (4.3.0) |
B | 2.10.25.10 | Mainly Beta | Ribbon | Laminin | Laminin | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00757 | Furin-like cysteine rich region (Furin-like) | Furin-like cysteine rich region | - | Domain | |
PF01030 | Receptor L domain (Recep_L_domain) | Receptor L domain | - | Repeat | |
PF14843 | Growth factor receptor domain IV (GF_recep_IV) | Growth factor receptor domain IV | This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1]. | Domain | |
PF00008 | EGF-like domain (EGF) | EGF-like domain | There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ... | Domain |