1OGK

The crystal structure of Trypanosoma cruzi dUTPase in complex with dUDP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ogka_	All alpha proteins	all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	Type II deoxyuridine triphosphatase	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
B	d1ogkb_	All alpha proteins	all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	Type II deoxyuridine triphosphatase	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
C [auth D]	d1ogkd_	All alpha proteins	all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	Type II deoxyuridine triphosphatase	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
D [auth E]	d1ogke_	All alpha proteins	all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	Type II deoxyuridine triphosphatase	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	all-alpha NTP pyrophosphatases	8037478	3001174	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	all-alpha NTP pyrophosphatases	8037478	3001174	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	all-alpha NTP pyrophosphatases	8037478	3001174	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	all-alpha NTP pyrophosphatases	8037478	3001174	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	dUTPase_2	e1ogkA1	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: Type II deoxyuridine triphosphatase-related	F: dUTPase_2	ECOD (1.6)
B	dUTPase_2	e1ogkB1	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: Type II deoxyuridine triphosphatase-related	F: dUTPase_2	ECOD (1.6)
C [auth D]	dUTPase_2	e1ogkD1	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: Type II deoxyuridine triphosphatase-related	F: dUTPase_2	ECOD (1.6)
D [auth E]	dUTPase_2	e1ogkE1	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: Type II deoxyuridine triphosphatase-related	F: dUTPase_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1680.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	CATH (4.3.0)
A	1.20.1670.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatase	Type II deoxyuridine triphosphatase	CATH (4.3.0)
B	1.20.1680.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	CATH (4.3.0)
B	1.20.1670.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatase	Type II deoxyuridine triphosphatase	CATH (4.3.0)
C [auth D]	1.20.1680.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	CATH (4.3.0)
C [auth D]	1.20.1670.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatase	Type II deoxyuridine triphosphatase	CATH (4.3.0)
D [auth E]	1.20.1680.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatases	Type II deoxyuridine triphosphatase	CATH (4.3.0)
D [auth E]	1.20.1670.10	Mainly Alpha	Up-down Bundle	all-alpha NTP pyrophosphatase	Type II deoxyuridine triphosphatase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth E]	PF08761	dUTPase (dUTPase_2)	dUTPase	2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23). Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the ...	2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23). Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms [1]. This family contains both dUTPase homologues of dUTPase including dCTPase of phage T4.	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth E]	IPR014871	dUTPase/dCTP pyrophosphatase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.