Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyBiotin dependent carboxylase carboxyltransferase domain 8019865 4000456 SCOP2 (2022-06-29)
ASCOP2 FamilyBiotin dependent carboxylase carboxyltransferase domain 8019866 4000456 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyClpP/crotonase 8032245 3000033 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyClpP/crotonase 8032246 3000033 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyClpP/crotonase 8032245 3000033 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyClpP/crotonase 8032246 3000033 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACarboxyl_trans_Ce1pixA1 A: a/b three-layered sandwichesX: ClpP/crotonase (From Topology)H: ClpP/crotonase (From Topology)T: ClpP/crotonaseF: Carboxyl_trans_CECOD (1.6)
BCarboxyl_trans_Ce1pixB1 A: a/b three-layered sandwichesX: ClpP/crotonase (From Topology)H: ClpP/crotonase (From Topology)T: ClpP/crotonaseF: Carboxyl_trans_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01039Carboxyl transferase domain (Carboxyl_trans)Carboxyl transferase domain- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Glutaconyl-CoA decarboxylase A subunit

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, B
glutaconyl-CoA decarboxylase  M-CSA #675

Bacterial Glutaconyl-CoA decarboxylase is an unusual ion transport holozyme, which uses the free energy released from the decarboxylation of glutaconyl CoA to crotonyl CoA in order to power the active transport of sodium ions into the periplasm. The carboxyl transferase subunit, GCDalpha is responsible for the first step in this process whereby the transfer of carbon dioxide to the biotin cofactor on GCDalpha is carried out. This subunit displays structural homology to the family of crotonases such as methylmalonoyl CoA decarboxylase, but little sequence identity, so although it clearly shares a common ancestor, divergence is likely to have occurred a long time in the past.

Defined by 4 residues: VAL:A-152 [auth A-151]GLY:A-195 [auth A-194]ILE:B-418 [auth B-417]ALA:B-458 [auth B-457]
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