Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyBacterial ribonucleases 8025984 4001841 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyMicrobial ribonucleases 8038363 3001847 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyMicrobial ribonucleases 8038363 3001847 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARibonucleasee1pylA1 A: a+b two layersX: Microbial ribonucleases-likeH: Microbial ribonucleases (From Topology)T: Microbial ribonucleasesF: RibonucleaseECOD (1.6)
BRibonucleasee1pylB1 A: a+b two layersX: Microbial ribonucleases-likeH: Microbial ribonucleases (From Topology)T: Microbial ribonucleasesF: RibonucleaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.450.30 Alpha Beta Roll Nuclear Transport Factor 2 Chain: A,CATH (4.3.0)
B3.10.450.30 Alpha Beta Roll Nuclear Transport Factor 2 Chain: A,CATH (4.3.0)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR000026Guanine-specific ribonuclease N1-likeFamily
A, B
IPR016191Ribonuclease/ribotoxinHomologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
guanyl-specific ribonuclease Sa  M-CSA #459

Three different strains of Streptomyces aureofaciens produce the homologous ribonucleases Sa, Sa2 and Sa3. They are all guanylate endoribonucleases, highly specifically hydrolysing the phosphodiester bonds of RNA at the 3'-side of guanosine nucleotides. These enzymes belong to the prokaryotic subgroup of microbial ribonucleases, and are some of the smallest enzymes known.

Defined by 4 residues: GLU:A-56ARG:A-67ARG:A-71HIS:A-86
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