Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamily6-hydroxymethyl-7, 8-dihydropterin pyrophosphokinase, HPPK 8044430 3001294 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHPPKe1q0nA1 A: a+b two layersX: Alpha-beta plaitsH: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK (From Topology)T: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPKF: HPPKECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.70.560 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPKCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF012887,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) (HPPK)7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase -

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase  M-CSA #151

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) catalyses the transfer of pyrophosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin(HP), the first reaction in the folate biosynthesis.

Folate cofactors are essential for life - they are required for the biosynthesis of purine and pyrimidine bases and certain amino acids. Mammals obtain folate from their diets by an active transport system. In contrast, many microorganisms lack the active transport system and must synthesise folate de novo. Therefore, enzymes in the folate biosynthesis pathway, including HPPK, are target for developing antimicrobial agents.

Defined by 4 residues: ARG:A-82ARG:A-92ASP:A-95ASP:A-97
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