1Q46
crystal structure of the eIF2 alpha subunit from saccharomyces cerevisia
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1q46a1 | All alpha proteins | SAM domain-like | eIF2alpha middle domain-like | eIF2alpha middle domain-like | Eukaryotic initiation factor 2alpha, eIF2alpha, domain 2 | (Saccharomyces cerevisiae ) [TaxId: 4932 ], | SCOPe (2.08) |
A | d1q46a2 | All beta proteins | OB-fold | Nucleic acid-binding proteins | Cold shock DNA-binding domain-like | Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain | (Saccharomyces cerevisiae ) [TaxId: 4932 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | eIF2alpha middle domain-like | 8029769 | 4002794 | SCOP2 (2022-06-29) |
A | SCOP2 Family | Cold shock DNA-binding domain-like | 8029770 | 4001909 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | eIF2alpha middle domain-like | 8042148 | 3001761 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Nucleic acid-binding proteins | 8042149 | 3000135 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | S1_1 | e1q46A1 | A: beta barrels | X: OB-fold | H: Nucleic acid-binding proteins (From Topology) | T: Nucleic acid-binding proteins | F: S1_1 | ECOD (1.6) |
A | EIF_2_alpha_N | e1q46A2 | A: alpha arrays | X: HhH/H2TH | H: eIF2alpha middle domain (From Topology) | T: eIF2alpha middle domain | F: EIF_2_alpha_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.40.50.140 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | Nucleic acid-binding proteins | CATH (4.3.0) |
A | 1.10.150.190 | Mainly Alpha | Orthogonal Bundle | DNA polymerase | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF07541 | Eukaryotic translation initiation factor 2 alpha subunit (EIF_2_alpha) | Eukaryotic translation initiation factor 2 alpha subunit | - | Family | |
PF00575 | S1 RNA binding domain (S1) | S1 RNA binding domain | The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003029 | S1 domain | Domain | |
IPR044126 | IF2a, S1-like domain | Domain | |
IPR024054 | Translation initiation factor 2, alpha subunit, middle domain superfamily | Homologous Superfamily | |
IPR012340 | Nucleic acid-binding, OB-fold | Homologous Superfamily | |
IPR024055 | Translation initiation factor 2, alpha subunit, C-terminal | Homologous Superfamily | |
IPR011488 | Translation initiation factor 2, alpha subunit | Family |