1QH4

CRYSTAL STRUCTURE OF CHICKEN BRAIN-TYPE CREATINE KINASE AT 1.41 ANGSTROM RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1qh4a1	All alpha proteins	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Creatine kinase, N-domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d1qh4a2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Guanido kinase catalytic domain	Creatine kinase, C-terminal domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d1qh4b1	All alpha proteins	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Creatine kinase, N-domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d1qh4b2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Guanido kinase catalytic domain	Creatine kinase, C-terminal domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d1qh4c1	All alpha proteins	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Creatine kinase, N-domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d1qh4c2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Guanido kinase catalytic domain	Creatine kinase, C-terminal domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
D	d1qh4d1	All alpha proteins	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	Creatine kinase, N-domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
D	d1qh4d2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Guanido kinase catalytic domain	Creatine kinase, C-terminal domain	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Guanido kinase catalytic domain	8023908	4002008	SCOP2 (2022-06-29)
A	SCOP2 Family	Guanido kinase N-terminal domain	8025636	4001090	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glutamine synthetase/guanido kinase	8036287	3000676	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Guanido kinase N-terminal domain	8038015	3000726	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8036287	3000676	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Guanido kinase N-terminal domain	8038015	3000726	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Guanido kinase N-terminal domain	8038015	3000726	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8036287	3000676	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Guanido kinase N-terminal domain	8038015	3000726	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8036287	3000676	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ATP-gua_PtransN	e1qh4A1	A: alpha arrays	X: Guanido kinase-N (From Topology)	H: Guanido kinase-N (From Topology)	T: Guanido kinase-N	F: ATP-gua_PtransN	ECOD (1.6)
A	ATP-gua_Ptrans	e1qh4A2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: ATP-gua_Ptrans	ECOD (1.6)
B	ATP-gua_PtransN	e1qh4B1	A: alpha arrays	X: Guanido kinase-N (From Topology)	H: Guanido kinase-N (From Topology)	T: Guanido kinase-N	F: ATP-gua_PtransN	ECOD (1.6)
B	ATP-gua_Ptrans	e1qh4B2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: ATP-gua_Ptrans	ECOD (1.6)
C	ATP-gua_PtransN	e1qh4C1	A: alpha arrays	X: Guanido kinase-N (From Topology)	H: Guanido kinase-N (From Topology)	T: Guanido kinase-N	F: ATP-gua_PtransN	ECOD (1.6)
C	ATP-gua_Ptrans	e1qh4C2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: ATP-gua_Ptrans	ECOD (1.6)
D	ATP-gua_PtransN	e1qh4D1	A: alpha arrays	X: Guanido kinase-N (From Topology)	H: Guanido kinase-N (From Topology)	T: Guanido kinase-N	F: ATP-gua_PtransN	ECOD (1.6)
D	ATP-gua_Ptrans	e1qh4D2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: ATP-gua_Ptrans	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.135.10	Mainly Alpha	Orthogonal Bundle	Transferase Creatine Kinase	Chain A, domain 1	CATH (4.3.0)
A	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
B	1.10.135.10	Mainly Alpha	Orthogonal Bundle	Transferase Creatine Kinase	Chain A, domain 1	CATH (4.3.0)
B	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
C	1.10.135.10	Mainly Alpha	Orthogonal Bundle	Transferase Creatine Kinase	Chain A, domain 1	CATH (4.3.0)
C	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
D	1.10.135.10	Mainly Alpha	Orthogonal Bundle	Transferase Creatine Kinase	Chain A, domain 1	CATH (4.3.0)
D	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00217	ATP:guanido phosphotransferase, C-terminal catalytic domain (ATP-gua_Ptrans)	ATP:guanido phosphotransferase, C-terminal catalytic domain	The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.	Domain
A, B, C, D	PF02807	ATP:guanido phosphotransferase, N-terminal domain (ATP-gua_PtransN)	ATP:guanido phosphotransferase, N-terminal domain	The N-terminal domain has an all-alpha fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	CREATINE KINASE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding creatine kinase activity kinase activity transferase activity catalytic activity phosphotransferase activity, nitrogenous group as acceptor transferase activity, transferring phosphorus-containing groups	phosphocreatine metabolic process phosphagen metabolic process phosphocreatine biosynthetic process cellular metabolic process cellular modified amino acid metabolic process phosphagen biosynthetic process biosynthetic process organophosphate metabolic process cellular modified amino acid biosynthetic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process phosphocreatine metabolic process phosphagen metabolic process phosphocreatine biosynthetic process cellular metabolic process cellular modified amino acid metabolic process phosphagen biosynthetic process biosynthetic process organophosphate metabolic process cellular modified amino acid biosynthetic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process small molecule metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular organelle extracellular region extracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular organelle extracellular region extracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR022413	ATP:guanido phosphotransferase, N-terminal	Domain
A, B, C, D	IPR022414	ATP:guanido phosphotransferase, catalytic domain	Domain
A, B, C, D	IPR036802	ATP:guanido phosphotransferase, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR000749	ATP:guanido phosphotransferase	Family
A, B, C, D	IPR022415	ATP:guanido phosphotransferase active site	Active Site
A, B, C, D	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.