1QUN

X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd1qunb2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1qunb1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd1qund2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd1qund1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Fd1qunf2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Fd1qunf1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Hd1qunh2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Hd1qunh1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Jd1qunj2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Jd1qunj1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ld1qunl2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ld1qunl1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Nd1qunn2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Nd1qunn1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Pd1qunp2 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Pd1qunp1 All beta proteins Common fold of diphtheria toxin/transcription factors/cytochrome f Bacterial adhesins Pilus subunits Mannose-specific adhesin FimH, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1quna1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1quna2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1qunc1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1qunc2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1qune1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1qune2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd1qung1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd1qung2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Id1quni1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Id1quni2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Kd1qunk1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Kd1qunk2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Md1qunm1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Md1qunm2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Od1quno1 All beta proteins Immunoglobulin-like beta-sandwich PapD-like Pilus chaperone Periplasmic chaperone FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Od1quno2 All beta proteins C2 domain-like Periplasmic chaperone C-domain Periplasmic chaperone C-domain FimC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
PSCOP2B SuperfamilyBacterial adhesin-like 8032980 3000723 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyPapD-like 8055315 3002067 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyPeriplasmic chaperone C-domain 8035665 3000998 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BFimH_man-binde1qunB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
BFimbrial_1e1qunB2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
DFimH_man-binde1qunD1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
DFimbrial_1e1qunD2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
FFimH_man-binde1qunF1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
FFimbrial_1e1qunF2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
HFimH_man-binde1qunH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
HFimbrial_1e1qunH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
JFimH_man-binde1qunJ1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
JFimbrial_1e1qunJ2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
LFimH_man-binde1qunL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
LFimbrial_1e1qunL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
NFimH_man-binde1qunN1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
NFimbrial_1e1qunN2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
PFimH_man-binde1qunP1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: FimH_man-bindECOD (1.6)
PFimbrial_1e1qunP2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: Fimbrial_1ECOD (1.6)
APapD_Ce1qunA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
APapD_Ne1qunA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
CPapD_Ce1qunC1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
CPapD_Ne1qunC2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
EPapD_Ce1qunE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
EPapD_Ne1qunE2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
GPapD_Ce1qunG1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
GPapD_Ne1qunG2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
IPapD_Ce1qunI1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
IPapD_Ne1qunI2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
KPapD_Ce1qunK1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
KPapD_Ne1qunK2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
MPapD_Ce1qunM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
MPapD_Ne1qunM2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)
OPapD_Ce1qunO1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_CECOD (1.6)
OPapD_Ne1qunO2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PapD_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D, F, H, J
PF00419Fimbrial protein (Fimbrial)Fimbrial protein- Domain
B, D, F, H, J
PF09160FimH, mannose binding (FimH_man-bind)FimH, mannose bindingMembers of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding ...Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose [1].
Domain
A, C, E, G, I
PF02753Pili assembly chaperone PapD, C-terminal domain (PapD_C)Pili assembly chaperone PapD, C-terminal domainIg-like beta-sandwich fold. This domain is the C-terminal part of the pilus and flagellar-assembly chaperone protein PapD.Domain
A, C, E, G, I
PF00345Pili and flagellar-assembly chaperone, PapD N-terminal domain (PapD_N)Pili and flagellar-assembly chaperone, PapD N-terminal domainC2 domain-like beta-sandwich fold. This domain is the n-terminal part of the PapD chaperone protein for pilus and flagellar assembly.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B, D, F, H, J
MANNOSE-SPECIFIC ADHESIN FIMH
A, C, E, G, I
PAPD-LIKE CHAPERONE FIMC

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
B, D, F, H, J
IPR036937Fimbrial-type adhesion domain superfamilyHomologous Superfamily
B, D, F, H, J
IPR015243FimH, mannose-binding domainDomain
B, D, F, H, J
IPR050263Bacterial Fimbrial AdherenceFamily
B, D, F, H, J
IPR000259Fimbrial-type adhesion domainDomain
B, D, F, H, J
IPR008966Adhesion domain superfamilyHomologous Superfamily
A, C, E, G, I
IPR036316Pili assembly chaperone, C-terminal domain superfamilyHomologous Superfamily
A, C, E, G, I
IPR013783Immunoglobulin-like foldHomologous Superfamily
A, C, E, G, I
IPR050643Periplasmic Pilus ChaperoneFamily
A, C, E, G, I
IPR016148Pili assembly chaperone, C-terminalDomain
A, C, E, G, I
IPR008962PapD-like superfamilyHomologous Superfamily
A, C, E, G, I
IPR016147Pili assembly chaperone, N-terminalDomain
A, C, E, G, I
IPR001829Pili assembly chaperone, bacterialFamily
A, C, E, G, I
IPR018046Pili assembly chaperone, conserved siteConserved Site