1RO7

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analogue, CMP-3FNeuAc.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ro7a_	Alpha and beta proteins (a/b)	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	(Campylobacter jejuni ) [TaxId: 197 ],	SCOPe (2.08)
B	d1ro7b_	Alpha and beta proteins (a/b)	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	(Campylobacter jejuni ) [TaxId: 197 ],	SCOPe (2.08)
C	d1ro7c_	Alpha and beta proteins (a/b)	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	(Campylobacter jejuni ) [TaxId: 197 ],	SCOPe (2.08)
D	d1ro7d_	Alpha and beta proteins (a/b)	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	Alpha-2,3/8-sialyltransferase CstII	(Campylobacter jejuni ) [TaxId: 197 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Alpha-2, 3/8-sialyltransferase CstII	8028400	4001079	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sialyltransferase/TPK catalytic domain-like	8040779	3000683	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Sialyltransferase/TPK catalytic domain-like	8040779	3000683	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Sialyltransferase/TPK catalytic domain-like	8040779	3000683	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Sialyltransferase/TPK catalytic domain-like	8040779	3000683	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CST-I	e1ro7A1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: CST-I	ECOD (1.6)
B	CST-I	e1ro7B1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: CST-I	ECOD (1.6)
C	CST-I	e1ro7C1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: CST-I	ECOD (1.6)
D	CST-I	e1ro7D1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: CST-I	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.1480.10	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Alpha-2,3-sialyltransferase	CATH (4.3.0)
B	3.90.1480.10	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Alpha-2,3-sialyltransferase	CATH (4.3.0)
C	3.90.1480.10	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Alpha-2,3-sialyltransferase	CATH (4.3.0)
D	3.90.1480.10	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Alpha-2,3-sialyltransferase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF06002	Alpha-2,3-sialyltransferase (CST-I) (CST-I)	Alpha-2,3-sialyltransferase (CST-I)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	alpha-2,3/8-sialyltransferase	glycosyltransferase activity transferase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036715	Alpha-2,3-sialyltransferase superfamily	Homologous Superfamily
A, B, C, D	IPR009251	Alpha-2,3-sialyltransferase	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	alpha-2,3-sialyltransferase M-CSA #840	Sialyltransferase (CstII) from Campylobacter jejuni catalyses the transfer of the sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuramic acid (CMP-NeuAc) to the terminal positions of glycoconjugates. The products play critical roles in recognition and adherence. Campylobacter jejuni has been shown to express variable cell surface carbohydrate mimics of human gangliosides that are associated with virulence.	Defined by 4 residues: ARG:A-129TYR:A-156TYR:A-162HIS:A-188 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 2.4.99 (PDB Primary Data) Search M-CSA Motif + EC 2.4.99

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.