1RPY

CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rpya_	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	Adaptor protein Aps	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1rpyb_	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	Adaptor protein Aps	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SH2 domain	8028447	4001650	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SH2 domain	8040826	3000197	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	SH2 domain	8040826	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH2	e1rpyA1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
B	SH2	e1rpyB1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
B	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	adaptor protein APS	transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding molecular adaptor activity signaling adaptor activity protein binding signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity SH2 domain binding transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding molecular adaptor activity signaling adaptor activity protein binding signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity SH2 domain binding protein domain specific binding identical protein binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process signal transduction immune response-regulating cell surface receptor signaling pathway positive regulation of biological process positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response regulation of signaling small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction Ras protein signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of Ras protein signal transduction intracellular signaling cassette regulation of cell communication cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization metabolic process regulation of metabolic process cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to insulin cellular response to insulin stimulus developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process B-1 B cell homeostasis homeostasis of number of cells lymphocyte homeostasis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane ruffle cell projection cell leading edge plasma membrane bounded cell projection actin filament bundle actin cytoskeleton actomyosin intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane ruffle cell projection cell leading edge plasma membrane bounded cell projection actin filament bundle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle stress fiber contractile actin filament bundle non-membrane-bounded organelle polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR015012	Phenylalanine zipper	Domain
A, B	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B	IPR000980	SH2 domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR035058	SH2B2, SH2 domain	Domain
A, B	IPR036290	Phenylalanine zipper superfamily	Homologous Superfamily
A, B	IPR030523	SH2B adapter protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.