Annotations: 1RVV

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rvva_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
BA [auth 2]	d1rvv2_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
G	d1rvvg_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
H	d1rvvh_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
J	d1rvvj_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
K	d1rvvk_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
L	d1rvvl_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
M	d1rvvm_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
O	d1rvvo_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
Q	d1rvvq_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
S	d1rvvs_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
V	d1rvvv_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
W	d1rvvw_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
X	d1rvvx_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
Z	d1rvvz_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
AA [auth 1]	d1rvv1_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
B	d1rvvb_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
C	d1rvvc_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
CA [auth 3]	d1rvv3_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
D	d1rvvd_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
DA [auth 4]	d1rvv4_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
E	d1rvve_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
F	d1rvvf_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
I	d1rvvi_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
N	d1rvvn_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
P	d1rvvp_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
R	d1rvvr_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
T	d1rvvt_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
U	d1rvvu_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
Y	d1rvvy_	Alpha and beta proteins (a/b)	Lumazine synthase	Lumazine synthase	Lumazine synthase	Lumazine synthase	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Lumazine synthase	8031635	4003586	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Lumazine synthase	8044013	3001085	SCOP2 (2022-06-29)
BA [auth 2]	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
Z	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
AA [auth 1]	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
CA [auth 3]	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
DA [auth 4]	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)
Y	SCOP2B Superfamily	Lumazine synthase	8044013	3001085	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DMRL_synthase	e1rvvA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
BA [auth 2]	DMRL_synthase	e1rvv21	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
G	DMRL_synthase	e1rvvG1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
H	DMRL_synthase	e1rvvH1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
J	DMRL_synthase	e1rvvJ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
K	DMRL_synthase	e1rvvK1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
L	DMRL_synthase	e1rvvL1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
M	DMRL_synthase	e1rvvM1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
O	DMRL_synthase	e1rvvO1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
Q	DMRL_synthase	e1rvvQ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
S	DMRL_synthase	e1rvvS1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
V	DMRL_synthase	e1rvvV1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
W	DMRL_synthase	e1rvvW1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
X	DMRL_synthase	e1rvvX1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
Z	DMRL_synthase	e1rvvZ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
AA [auth 1]	DMRL_synthase	e1rvv11	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
B	DMRL_synthase	e1rvvB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
C	DMRL_synthase	e1rvvC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
CA [auth 3]	DMRL_synthase	e1rvv31	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
D	DMRL_synthase	e1rvvD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
DA [auth 4]	DMRL_synthase	e1rvv41	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
E	DMRL_synthase	e1rvvE1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
F	DMRL_synthase	e1rvvF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
I	DMRL_synthase	e1rvvI1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
N	DMRL_synthase	e1rvvN1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
P	DMRL_synthase	e1rvvP1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
R	DMRL_synthase	e1rvvR1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
T	DMRL_synthase	e1rvvT1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
U	DMRL_synthase	e1rvvU1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)
Y	DMRL_synthase	e1rvvY1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Lumazine synthase	F: DMRL_synthase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
BA [auth 2]	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
G	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
H	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
J	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
K	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
L	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
M	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
O	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
Q	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
S	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
V	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
W	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
X	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
Z	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
AA [auth 1]	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
B	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
C	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
CA [auth 3]	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
D	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
DA [auth 4]	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
E	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
F	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
I	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
N	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
P	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
R	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
T	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
U	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)
Y	3.40.50.960	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Lumazine/riboflavin synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	PF00885	6,7-dimethyl-8-ribityllumazine synthase (DMRL_synthase)	6,7-dimethyl-8-ribityllumazine synthase	This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function f ...	This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example Swiss:O28856. The family contains a number of different subsets including a family of proteins comprising archaeal lumazine and riboflavin synthases, type I lumazine synthases, and the eubacterial type II lumazine synthases [1]. It has been established that lumazine synthase catalyses the penultimate step in the biosynthesis of riboflavin in plants and microorganisms. The type I lumazine synthases area active in pentameric or icosahedral quaternary assemblies, whereas the type II are decameric [2]. Brucella, a bacterial genus that causes brucellosis, and other Rhizobiales have an atypical riboflavin metabolic pathway. Brucella spp code for both a type-I and a type-II lumazine synthase, and it has been shown that at least one of these two has to be present in order for Brucella to be viable, showing that in the case of Brucella flavin metabolism is implicated in bacterial virulence [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	RIBOFLAVIN SYNTHASE	6,7-dimethyl-8-ribityllumazine synthase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity	water-soluble vitamin biosynthetic process small molecule biosynthetic process flavin-containing compound metabolic process vitamin biosynthetic process riboflavin biosynthetic process vitamin metabolic process flavin-containing compound biosynthetic process biosynthetic process metabolic process cellular process small molecule metabolic process water-soluble vitamin metabolic process riboflavin metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex riboflavin synthase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR036467	Lumazine/riboflavin synthase superfamily	Homologous Superfamily
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR034964	Lumazine synthase	Family
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR002180	Lumazine/riboflavin synthase	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	6,7-dimethyl-8-ribityllumazine synthase M-CSA #909	Riboflavin is biosynthesised in plants, fungi and certain microorganisms; as animals lack the necessary enzymes to produce this vitamin, they acquire it from dietary sources. The penultimate step in the biosynthesis of riboflavin (vitamin B2) involves the condensation of 3,4-dihydroxy-2-butanone 4-phosphate with 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is catalysed by 6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase).	Defined by 1 residue: HIS:A-88 \| Explore in 3D: M-CSA Motif Definition At least 2 residues must be present to support Structure Motif searching. EC: 2.5.1.78 (UniProt)