Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
M [auth A]d1rzta1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
M [auth A]d1rzta2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
M [auth A]d1rzta3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
N [auth E]d1rzte1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
N [auth E]d1rzte2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
N [auth E]d1rzte3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
O [auth I]d1rzti1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
O [auth I]d1rzti2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
O [auth I]d1rzti3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
P [auth M]d1rztm1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
P [auth M]d1rztm2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
P [auth M]d1rztm3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
M [auth A]SCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
M [auth A]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
M [auth A]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
N [auth E]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
N [auth E]SCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
N [auth E]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
O [auth I]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
O [auth I]SCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
O [auth I]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
P [auth M]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
P [auth M]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
P [auth M]SCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
M [auth A]DNA_pol_lambd_fe1rztA1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
M [auth A]HHH_8e1rztA2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
M [auth A]DNA_pol_B_palme1rztA3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
N [auth E]DNA_pol_lambd_fe1rztE1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
N [auth E]HHH_8e1rztE2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
N [auth E]DNA_pol_B_palme1rztE3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
O [auth I]DNA_pol_lambd_fe1rztI1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
O [auth I]HHH_8e1rztI2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
O [auth I]DNA_pol_B_palme1rztI3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
P [auth M]DNA_pol_lambd_fe1rztM1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
P [auth M]HHH_8e1rztM2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
P [auth M]DNA_pol_B_palme1rztM3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
M [auth A],
N [auth E],
O [auth I],
P [auth M]
PF14716Helix-hairpin-helix domain (HHH_8)Helix-hairpin-helix domain- Domain
M [auth A],
N [auth E],
O [auth I],
P [auth M]
PF14791DNA polymerase beta thumb (DNA_pol_B_thumb)DNA polymerase beta thumb- Family
M [auth A],
N [auth E],
O [auth I],
P [auth M]
PF14792DNA polymerase beta palm (DNA_pol_B_palm)DNA polymerase beta palmThe catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain [1].Domain
M [auth A],
N [auth E],
O [auth I],
P [auth M]
PF10391Fingers domain of DNA polymerase lambda (DNA_pol_lambd_f)Fingers domain of DNA polymerase lambdaDNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the centr ...DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
D [auth F],
G [auth J],
J [auth N]
5'-D(*CP*GP*GP*CP*AP*AP*CP*GP*CP*AP*C)-3'---
B [auth C],
E [auth G],
H [auth K],
K [auth O]
5'-D(*GP*TP*GP*CP*G)-3'---
C [auth D],
F [auth H],
I [auth L],
L [auth P]
5'-D(P*GP*CP*CP*G)-3'---
M [auth A],
N [auth E],
O [auth I],
P [auth M]
DNA polymerase lambda

Pharos: Disease Associations Pharos Homepage Annotation