Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1s3ua_ Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Dihydrofolate reductases, eukaryotic type human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDihydrofolate reductase-like 8040487 3001255 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADHFR_1e1s3uA1 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00186Dihydrofolate reductase (DHFR_1)Dihydrofolate reductase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Dihydrofolate reductase

Pharos: Disease Associations Pharos Homepage Annotation