1SYO

N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1syoa1	All beta proteins	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Cation-independent mannose-6-phosphate receptor (MIR-receptor)	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1syob1	All beta proteins	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Cation-independent mannose-6-phosphate receptor (MIR-receptor)	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8038461	3001527	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8038458	3001527	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8038459	3001527	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8038459	3001527	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8038461	3001527	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8038458	3001527	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CIMR	e1syoA3	A: beta barrels	X: Mannose 6-phosphate receptor domain (From Topology)	H: Mannose 6-phosphate receptor domain (From Topology)	T: Mannose 6-phosphate receptor domain	F: CIMR	ECOD (1.6)
B	CIMR	e1syoB3	A: beta barrels	X: Mannose 6-phosphate receptor domain (From Topology)	H: Mannose 6-phosphate receptor domain (From Topology)	T: Mannose 6-phosphate receptor domain	F: CIMR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.130.10	Mainly Beta	Distorted Sandwich	Cation-dependent Mannose-6-phosphate Receptor	Chain A	CATH (4.3.0)
B	2.70.130.10	Mainly Beta	Distorted Sandwich	Cation-dependent Mannose-6-phosphate Receptor	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00878	Cation-independent mannose-6-phosphate receptor repeat (CIMR)	Cation-independent mannose-6-phosphate receptor repeat	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	cation-independent mannose 6-phosphate receptor	binding D-mannose binding monosaccharide binding carbohydrate binding small molecule binding insulin-like growth factor binding protein binding growth factor binding molecular transducer activity signaling receptor activity phosphoprotein binding kringle domain binding protein domain specific binding	localization cellular localization transport establishment of localization in cell vacuolar transport intracellular transport cellular process lysosomal transport establishment of localization	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle trans-Golgi network cytoplasm Golgi membrane membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle trans-Golgi network cytoplasm Golgi membrane membrane bounding membrane of organelle organelle membrane cell surface endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle cell periphery plasma membrane late endosome endocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000479	Cation-independent mannose-6-phosphate receptor repeat	Repeat
A, B	IPR013806	Kringle-like fold	Homologous Superfamily
A, B	IPR036943	Fibronectin type II domain superfamily	Homologous Superfamily
A, B	IPR009011	Mannose-6-phosphate receptor binding domain superfamily	Homologous Superfamily
A, B	IPR044865	MRH domain	Domain
A, B	IPR000562	Fibronectin type II domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.