Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPurine and uridine phosphorylases 8041020 3000626 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPurine and uridine phosphorylases 8041020 3000626 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APNP_UDP_1e1t0uA1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Peptidyl-tRNA hydrolase-like (From Topology)T: Peptidyl-tRNA hydrolase-likeF: PNP_UDP_1ECOD (1.6)
BPNP_UDP_1e1t0uB1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Peptidyl-tRNA hydrolase-like (From Topology)T: Peptidyl-tRNA hydrolase-likeF: PNP_UDP_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1580 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Nucleoside phosphorylase domainCATH (4.3.0)
B3.40.50.1580 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Nucleoside phosphorylase domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01048Phosphorylase superfamily (PNP_UDP_1)Phosphorylase superfamilyMembers of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Uridine phosphorylase

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, B
uridine phosphorylase  M-CSA #787

The enzyme uridine phosphorylase is very important in the pathway whereby uracil can be scavenged to increase blood uracil levels. The overall reaction thus results in the formation of ribose-1-phosphate in addition to uracil. The pathway is of particular interest because it provides a mechanism whereby the effect of base analogues such as 5BU can be minimised, thus may provide some defence against tumour formation. The enzyme itself shows significant homology to Purine nucleotide phosphorylases rather than to pyrimidine nucleotide phosphorylases, posing interesting questions about its evolution.

Defined by 4 residues: HIS:A-8GLU:A-80ARG:A-168ARG:B-223
Some residues are not modelled and lack atomic coordinates. Visualization is not available.
Some residues are not modelled and lack atomic coordinates. Structure Motif searching is not available.
EC: 2.4.2.3 (PDB Primary Data)