Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCoA-transferase family III (CaiB/BaiF) 8037531 3000607 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCoA-transferase family III (CaiB/BaiF) 8037531 3000607 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACoA_transf_3e1t4cA1 A: a/b three-layered sandwichesX: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)T: SurE-like/CoA-transferase family III (CaiB/BaiF)F: CoA_transf_3ECOD (1.6)
BCoA_transf_3e1t4cB1 A: a/b three-layered sandwichesX: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)T: SurE-like/CoA-transferase family III (CaiB/BaiF)F: CoA_transf_3ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF02515CoA-transferase family III (CoA_transf_3)CoA-transferase family III- Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, B
formyl-CoA transferase  M-CSA #155

Formyl-CoA transferase, sourced from Oxalobacter formigenes colonises the human gastrointestinal tract. It breaks down oxalate to generate ATP. Formyl-CoA transferase is a critical enzyme in oxalate-dependent ATP synthesis. It catalyses the transfer of CoA from formyl-CoA to oxalate, producing oxalyl-CoA and formate. It is of interest due to a correlation between absence of O. formigenes in humans and kidney stone formation due to elevated levels of oxalate in the blood. Secondly ATP production appears to depend solely on the anaerobic conversion of oxalate to formate and carbon dioxide - other carbohydrates cannot be used to replace oxalate as a growth substrate, implying that the organism lacks a functional glycolytic pathway.

Defined by 5 residues: GLN:A-16 [auth A-17]GLU:A-139 [auth A-140]ASP:A-168 [auth A-169]GLY:B-259 [auth B-260]GLY:B-260 [auth B-261]
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