1T7D
Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Membrane Protein Annotation: OPM
- Membrane Protein Annotation: mpstruc
- Protein Modification Annotation
- Structure Motif: Primary M-CSA Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1t7da_ | All beta proteins | LexA/Signal peptidase | LexA/Signal peptidase | Type 1 signal peptidase | Type 1 signal peptidase | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
B | d1t7db_ | All beta proteins | LexA/Signal peptidase | LexA/Signal peptidase | Type 1 signal peptidase | Type 1 signal peptidase | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Peptidase_S24_1 | e1t7dA2 | A: beta barrels | X: SH3 | H: LexA/Signal peptidase (From Topology) | T: LexA/Signal peptidase | F: Peptidase_S24_1 | ECOD (1.6) |
B | Peptidase_S24_1 | e1t7dB1 | A: beta barrels | X: SH3 | H: LexA/Signal peptidase (From Topology) | T: LexA/Signal peptidase | F: Peptidase_S24_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.10.109.10 | Mainly Beta | Ribbon | Umud Fragment, subunit A | Umud Fragment, subunit A | CATH (4.3.0) |
A | 2.170.230.10 | Mainly Beta | Beta Complex | Signal Peptidase I | Chain: A, domain 2 | CATH (4.3.0) |
B | 2.10.109.10 | Mainly Beta | Ribbon | Umud Fragment, subunit A | Umud Fragment, subunit A | CATH (4.3.0) |
B | 2.170.230.10 | Mainly Beta | Beta Complex | Signal Peptidase I | Chain: A, domain 2 | CATH (4.3.0) |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|---|---|---|---|
SIGNAL PEPTIDASE I | ||||
ARYLOMYCIN A2 | - | - | - |
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR019533 | Peptidase S26 | Domain | |
IPR019766 | Signal peptidase I, all-beta subdomain | Homologous Superfamily | |
IPR019756 | Peptidase S26A, signal peptidase I, serine active site | Active Site | |
IPR019758 | Peptidase S26A, signal peptidase I, conserved site | Conserved Site | |
IPR019757 | Peptidase S26A, signal peptidase I, lysine active site | Active Site | |
IPR036286 | LexA/Signal peptidase-like superfamily | Homologous Superfamily | |
IPR000223 | Peptidase S26A, signal peptidase I | Family |
Membrane Protein Annotation: OPM OPM Database Homepage
Chains | External Link | Type | Class | Superfamily | Family |
---|---|---|---|---|---|
OPM | Transmembrane | Alpha-helical polytopic | Peptidase SF | Peptidase S26 |
Membrane Protein Annotation: mpstruc mpstruc Database Homepage
Chains | Resource Link | Group | Subgroup | Protein |
---|---|---|---|---|
mpstruc | MONOTOPIC MEMBRANE PROTEINS | Peptidases | LepB Signal Peptidase (SPase) in complex with a lipopeptide inhibitor |
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
signal peptidase I M-CSA #635 | Escherichia coli type I signal peptidase is a membrane-bound serine endopeptidase that cleaves the amino-terminal signal sequence from secretory proteins and some membrane proteins. Evolutionarily the enzyme belongs to the protease clan SF and the protease family S26. | Defined by 4 residues: SER:B-15 [auth B-88]SER:B-17 [auth B-90]LYS:B-72 [auth B-145]SER:B-205 [auth B-278] | EC: 3.4.21.89 (PDB Primary Data) |