Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1tkka1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Ad1tkka2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Bd1tkkb1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Bd1tkkb2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Cd1tkkc1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Cd1tkkc2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Dd1tkkd1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Dd1tkkd2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Ed1tkke1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Ed1tkke2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Fd1tkkf1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Fd1tkkf2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Gd1tkkg1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Gd1tkkg2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Hd1tkkh1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Enolase C-terminal domain-like D-glucarate dehydratase-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)
Hd1tkkh2 Alpha and beta proteins (a+b) Enolase N-terminal domain-like Enolase N-terminal domain-like Enolase N-terminal domain-like L-Ala-D/L-Glu epimerase (Bacillus subtilis ) [TaxId: 1423 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyEnolase N-terminal domain-like 8037198 3001064 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyEnolase C-terminal domain-like 8037196 3000476 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMR_MLE_Ne1tkkA1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
AMR_MLE_C_1e1tkkA2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
BMR_MLE_Ne1tkkB1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
BMR_MLE_C_1e1tkkB2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
CMR_MLE_Ne1tkkC1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
CMR_MLE_C_1e1tkkC2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
DMR_MLE_Ne1tkkD1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
DMR_MLE_C_1e1tkkD2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
EMR_MLE_Ne1tkkE1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
EMR_MLE_C_1e1tkkE2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
FMR_MLE_Ne1tkkF1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
FMR_MLE_C_1e1tkkF2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
GMR_MLE_Ne1tkkG1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
GMR_MLE_C_1e1tkkG2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)
HMR_MLE_Ne1tkkH1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Enolase N-terminal domain-like (From Topology)T: Enolase N-terminal domain-likeF: MR_MLE_NECOD (1.6)
HMR_MLE_C_1e1tkkH2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MR_MLE_C_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02746Mandelate racemase / muconate lactonizing enzyme, N-terminal domain (MR_MLE_N)Mandelate racemase / muconate lactonizing enzyme, N-terminal domainSCOP reports fold similarity with enolase N-terminal domain.Domain
A, B, C, D, E
PF13378Enolase C-terminal domain-like (MR_MLE_C)Enolase C-terminal domain-likeThis domain appears at the C-terminus of many of the proteins that carry the MR_MLE_N Pfam:PF02746 domain. EC:4.2.1.40.Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR029065Enolase C-terminal domain-likeDomain
A, B, C, D, E
IPR013341Mandelate racemase/muconate lactonizing enzyme, N-terminal domainDomain
A, B, C, D, E
IPR034603Dipeptide epimeraseFamily
A, B, C, D, E
IPR013342Mandelate racemase/muconate lactonizing enzyme, C-terminalDomain
A, B, C, D, E
IPR029017Enolase-like, N-terminalHomologous Superfamily
A, B, C, D, E
IPR036849Enolase-like, C-terminal domain superfamilyHomologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
L-Ala-D/L-Glu epimerase  M-CSA #957

L-Ala-D/L-Glu epimerase, first characterised from the bacteria Escherichia coli and Bacillus subtilis, catalyses the epimerisation of L-Ala-D-Glu to L-Ala-L-Glu and is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. In vitro the enzyme from Escherichia coli has been shown to epimerise several L-Ala-L-X dipeptides with broader specificity than the enzyme from Bacillus subtilis.

Defined by 5 residues: LYS:A-162ASP:A-191GLU:A-219ASP:A-244LYS:A-268
 | 
 
Explore in 3DM-CSA Motif Definition