Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyNitrile hydratase alpha chain 8028458 4002201 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyNitrile hydratase alpha chain 8040837 3000945 SCOP2 (2022-06-29)
BSCOP2 FamilyNitrile hydratase beta chain 8028459 4001743 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyElectron transport accessory proteins 8040838 3000325 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ANHase_alphae1ugpA1 A: a+b complex topologyX: Nitrile hydratase alpha chain (From Topology)H: Nitrile hydratase alpha chain (From Topology)T: Nitrile hydratase alpha chainF: NHase_alphaECOD (1.6)
BNHase_beta_Ce1ugpB2 A: beta barrelsX: SH3H: SH3T: SH3F: NHase_beta_CECOD (1.6)
BNHase_beta_Ne1ugpB3 A: alpha arraysX: Nitrile hydratase subunit beta N-termial domain (From Topology)H: Nitrile hydratase subunit beta N-termial domain (From Topology)T: Nitrile hydratase subunit beta N-termial domainF: NHase_beta_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase Chain ACATH (4.3.0)
B1.10.472.20 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
B2.30.30.50 Mainly Beta Roll SH3 type barrels. CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02979Nitrile hydratase, alpha chain (NHase_alpha)Nitrile hydratase, alpha chain- Domain
PF02211Nitrile hydratase beta subunit, C-terminal (NHase_beta_C)Nitrile hydratase beta subunit, C-terminalNitrile hydratases (NHase) EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as ...Nitrile hydratases (NHase) EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile hydratases are composed of two subunits, alpha and beta, and they contain one iron atom per alpha beta unit [1]. Beta subunit consists of an N-terminal helical domain and a C-terminal SH3-like domain (represented in this entry) [2,3]. Thiocyanate hydrolase (SCNase) is a member of the NHase family, comprises alpha, beta and gamma subunits which share amino acid sequence similarities with NHase beta subunit C-terminal, beta subunit N-terminal and NHase alpha subunit, respectively [3].
Domain
PF21006Nitrile hydratase beta subunit, N-terminal (NHase_beta_N)Nitrile hydratase beta subunit, N-terminalNitrile hydratases (NHases) EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as ...Nitrile hydratases (NHases) EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile hydratases are composed of two subunits, alpha and beta, and they contain one iron atom per alpha beta unit [1]. Beta subunit consists of an N-terminal helical domain, represented in this entry, and a C-terminal SH3-like domain (Pfam:PF02211) [2,3]. Thiocyanate hydrolase (SCNase) is a member of the NHase family and comprises alpha, beta and gamma subunits, which share amino acid sequence similarities with NHase beta subunit C-terminal, beta subunit N-terminal and NHase alpha subunit, respectively [3].
Domain

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
CSD Parent Component: CYS

RESIDAA0262

PSI-MOD :  L-cysteine sulfinic acid MOD:00267
CSO Parent Component: CYS

RESIDAA0262 , AA0205

PSI-MOD :  L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfenic acid MOD:00210