1UUH

Hyaluronan binding domain of human CD44

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uuha_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Link domain	CD44, hyaluronan binding domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1uuhb_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Link domain	CD44, hyaluronan binding domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Link domain	8022752	4002511	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-type lectin-like	8035132	3001261	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	C-type lectin-like	8035132	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Xlink	e1uuhA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Xlink	ECOD (1.6)
B	Xlink	e1uuhB1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Xlink	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00193	Extracellular link domain (Xlink)	Extracellular link domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CD44 ANTIGEN	collagen binding protein-containing complex binding binding glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of cysteine-type endopeptidase activity negative regulation of programmed cell death regulation of protein metabolic process regulation of apoptotic process negative regulation of metabolic process regulation of peptidase activity negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process cell death regulation of molecular function negative regulation of apoptotic process regulation of hydrolase activity negative regulation of cysteine-type endopeptidase activity metabolic process macromolecule metabolic process apoptotic process regulation of metabolic process programmed cell death positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator negative regulation of cell communication cellular response to stress response to stress regulation of response to stress regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction DNA damage response signal transduction in response to DNA damage positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of cellular metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation cell migration cell motility response to fibroblast growth factor cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus response to growth factor cellular response to fibroblast growth factor stimulus monocyte aggregation cell-cell adhesion leukocyte cell-cell adhesion leukocyte aggregation regulation of cellular component organization regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of cell morphogenesis cellular component organization cell projection morphogenesis regulation of lamellipodium organization regulation of lamellipodium morphogenesis cellular component organization or biogenesis regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization regulation of cell projection organization anatomical structure morphogenesis lamellipodium organization lamellipodium morphogenesis regulation of plasma membrane bounded cell projection organization T cell activation immune system process cell activation lymphocyte activation leukocyte activation regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion defense response inflammatory response positive regulation of monocyte aggregation positive regulation of leukocyte cell-cell adhesion regulation of leukocyte cell-cell adhesion regulation of monocyte aggregation wound healing epithelium development morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet tissue morphogenesis epiboly wound healing, spreading of cells response to wounding mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface intracellular anatomical structure cytoplasm cytosol basal part of cell basal plasma membrane basolateral plasma membrane protein-containing complex macrophage migration inhibitory factor receptor complex receptor complex cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection lamellipodium membrane cell projection membrane lamellipodium intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle organelle membrane secretory granule membrane Golgi apparatus actin-based cell projection microvillus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001231	CD44 antigen	Family
A, B	IPR016187	C-type lectin fold	Homologous Superfamily
A, B	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B	IPR000538	Link domain	Domain
A, B	IPR043210	CD44 antigen-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P16070	vitiligo acute myeloid leukemia acute promyelocytic leukemia IgA glomerulonephritis Mammary Neoplasms, Experimental classic familial adenomatous polyposis contact dermatitis Sjogren syndrome chronic obstructive pulmonary disease lung cancer lymphoplasmacytic lymphoma subependymal giant cell astrocytoma congestive heart failure malignant ependymoma ulcerative colitis vitiligo acute myeloid leukemia acute promyelocytic leukemia IgA glomerulonephritis Mammary Neoplasms, Experimental classic familial adenomatous polyposis contact dermatitis Sjogren syndrome chronic obstructive pulmonary disease lung cancer lymphoplasmacytic lymphoma subependymal giant cell astrocytoma congestive heart failure malignant ependymoma ulcerative colitis Crohn disease diabetes mellitus acute kidney failure ductal breast carcinoma in situ nephrosclerosis gastric cancer oligodendroglioma genetic intestinal polyposis pancreatic ductal adenocarcinoma hematologic disease peripheral nervous system disease asthma pituitary cancer autoimmune disease invasive ductal breast carcinoma psoriasis breast disease limb-girdle muscular dystrophy lung disease skin disease Lynch syndrome systemic lupus erythematosus malignant glioma uterine corpus leiomyoma Down syndrome myopathy Emery-Dreifuss muscular dystrophy gastric carcinoma ovarian cancer adrenal cortex carcinoma glioblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hereditary diffuse gastric adenocarcinoma peripheral neuropathy astrocytic tumor hypothyroidism Becker muscular dystrophy juvenile dermatomyositis rheumatoid arthritis cancer liver disease lymphatic system disease stomach disease colonic disease malignant colon neoplasm tuberculosis malignant mesothelioma vertebral column disease dermatomyositis malignant pancreatic neoplasm Duchenne muscular dystrophy facioscapulohumeral muscular dystrophy gastric neoplasm ovarian disease Hashimoto thyroiditis pancreatic neoplasm pilocytic astrocytoma atypical teratoid rhabdoid tumor prostate disease brain disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.