Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1v2aa1 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Ad1v2aa2 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like Glutathione S-transferase (GST), N-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Bd1v2ab1 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Bd1v2ab2 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like Glutathione S-transferase (GST), N-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Cd1v2ac1 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Cd1v2ac2 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like Glutathione S-transferase (GST), N-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Dd1v2ad1 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)
Dd1v2ad2 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like Glutathione S-transferase (GST), N-terminal domain Class delta GST (Anopheles dirus ) [TaxId: 7168 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyGlutathione S-transferase (GST), C-terminal domain 8022984 4000976 SCOP2 (2022-06-29)
ASCOP2 FamilyGlutathione S-transferase (GST), N-terminal domain 8022985 4000472 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyGST C-terminal domain-like 8035364 3000305 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyThioredoxin-like 8035365 3000031 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyGST C-terminal domain-like 8035364 3000305 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThioredoxin-like 8035365 3000031 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThioredoxin-like 8035365 3000031 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGST C-terminal domain-like 8035364 3000305 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThioredoxin-like 8035365 3000031 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyGST C-terminal domain-like 8035364 3000305 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGST_C_3e1v2aA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
AGST_Ne1v2aA2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_NECOD (1.6)
BGST_C_3e1v2aB1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
BGST_Ne1v2aB2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_NECOD (1.6)
CGST_C_3e1v2aC1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
CGST_Ne1v2aC2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_NECOD (1.6)
DGST_C_3e1v2aD1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
DGST_Ne1v2aD2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF13417Glutathione S-transferase, N-terminal domain (GST_N_3)Glutathione S-transferase, N-terminal domain- Domain
A, B, C, D
PF00043Glutathione S-transferase, C-terminal domain (GST_C)Glutathione S-transferase, C-terminal domainGST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins ...GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain [1]. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes [2].
Domain