Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8033643 3000118 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8033643 3000118 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APRK09328_likee1vq1A1 A: alpha arraysX: SP1917-like (From Topology)H: SP1917-like (From Topology)T: SP1917-likeF: PRK09328_likeECOD (1.6)
AMethyltransf_11_2e1vq1A2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_2ECOD (1.6)
BPRK09328_likee1vq1B1 A: alpha arraysX: SP1917-like (From Topology)H: SP1917-like (From Topology)T: SP1917-likeF: PRK09328_likeECOD (1.6)
BMethyltransf_11_2e1vq1B2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.8.10 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
A3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
B1.10.8.10 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
B3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF17827PrmC N-terminal domain (PrmC_N)PrmC N-terminal domainThis entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors [3] ...This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors [3].
Domain
A, B
PF05175Methyltransferase small domain (MTS)Methyltransferase small domainThis domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742).Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
peptide chain release factor N5-glutamine methyltransferase  M-CSA #703

Post translational methylation of release factors on the glutamine residue of a conserved GGQ motif is required for efficient termination of protein synthesis. This methylation is performed by an N5-glutamine methyltransferase called HemK. Release factor 1 and 2 contain a conserved GGQ motif that is thought to play a role in activating or positioning the water molecule involved in hydrolysis at the peptidyl transferase active site.

Defined by 3 residues: PHE:A-112 [auth A-100]ASN:A-209 [auth A-197]PRO:A-210 [auth A-198]
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Explore in 3DM-CSA Motif Definition
EC: 2.1.1 (PDB Primary Data)