1W1I

Crystal structure of dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1w1ia1	All beta proteins	8-bladed beta-propeller	DPP6 N-terminal domain-like	DPP6 N-terminal domain-like	Dipeptidyl peptidase IV/CD26, N-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1w1ia2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	DPP6 catalytic domain-like	Dipeptidyl peptidase IV/CD26, C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1w1ib1	All beta proteins	8-bladed beta-propeller	DPP6 N-terminal domain-like	DPP6 N-terminal domain-like	Dipeptidyl peptidase IV/CD26, N-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1w1ib2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	DPP6 catalytic domain-like	Dipeptidyl peptidase IV/CD26, C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1w1ic1	All beta proteins	8-bladed beta-propeller	DPP6 N-terminal domain-like	DPP6 N-terminal domain-like	Dipeptidyl peptidase IV/CD26, N-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1w1ic2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	DPP6 catalytic domain-like	Dipeptidyl peptidase IV/CD26, C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1w1id1	All beta proteins	8-bladed beta-propeller	DPP6 N-terminal domain-like	DPP6 N-terminal domain-like	Dipeptidyl peptidase IV/CD26, N-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1w1id2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	DPP6 catalytic domain-like	Dipeptidyl peptidase IV/CD26, C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1w1ie_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Metallo-dependent hydrolases	Adenosine/AMP deaminase	Adenosine deaminase (ADA)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d1w1if_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Metallo-dependent hydrolases	Adenosine/AMP deaminase	Adenosine deaminase (ADA)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
G	d1w1ig_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Metallo-dependent hydrolases	Adenosine/AMP deaminase	Adenosine deaminase (ADA)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H	d1w1ih_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Metallo-dependent hydrolases	Adenosine/AMP deaminase	Adenosine deaminase (ADA)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8039750	3000102	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	DPP6 N-terminal domain-like	8039749	3001705	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DPP6 N-terminal domain-like	8039749	3001705	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8039750	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8039750	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DPP6 N-terminal domain-like	8039749	3001705	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	DPP6 N-terminal domain-like	8039749	3001705	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta-Hydrolases	8039750	3000102	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Metallo-dependent hydrolases	8032391	3000428	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Metallo-dependent hydrolases	8032391	3000428	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Metallo-dependent hydrolases	8032391	3000428	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Metallo-dependent hydrolases	8032391	3000428	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DPPIV_N	e1w1iA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: DPPIV_N	ECOD (1.6)
A	Hydrolase_4	e1w1iA2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
B	DPPIV_N	e1w1iB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: DPPIV_N	ECOD (1.6)
B	Hydrolase_4	e1w1iB2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
C	DPPIV_N	e1w1iC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: DPPIV_N	ECOD (1.6)
C	Hydrolase_4	e1w1iC2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
D	DPPIV_N	e1w1iD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: DPPIV_N	ECOD (1.6)
D	Hydrolase_4	e1w1iD2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
E	A_deaminase	e1w1iE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: A_deaminase	ECOD (1.6)
F	A_deaminase	e1w1iF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: A_deaminase	ECOD (1.6)
G	A_deaminase	e1w1iG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: A_deaminase	ECOD (1.6)
H	A_deaminase	e1w1iH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: A_deaminase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.140.10.30	Mainly Beta	8 Propeller	Methanol Dehydrogenase	Chain A	CATH (4.3.0)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	2.140.10.30	Mainly Beta	8 Propeller	Methanol Dehydrogenase	Chain A	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	2.140.10.30	Mainly Beta	8 Propeller	Methanol Dehydrogenase	Chain A	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	2.140.10.30	Mainly Beta	8 Propeller	Methanol Dehydrogenase	Chain A	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
E	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)
F	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)
G	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)
H	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00930	Dipeptidyl peptidase IV (DPP IV) N-terminal region (DPPIV_N)	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	Repeat
A, B, C, D	PF00326	Prolyl oligopeptidase family (Peptidase_S9)	Prolyl oligopeptidase family	-	Domain
E, F, G, H	PF00962	Adenosine deaminase (A_deaminase)	Adenosine deaminase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	DIPEPTIDYL PEPTIDASE IV	protein binding binding virus receptor activity exogenous protein binding peptidase activity catalytic activity, acting on a protein dipeptidyl-peptidase activity hydrolase activity exopeptidase activity catalytic activity signaling receptor binding enzyme binding protease binding serine hydrolase activity protein binding binding virus receptor activity exogenous protein binding peptidase activity catalytic activity, acting on a protein dipeptidyl-peptidase activity hydrolase activity exopeptidase activity catalytic activity signaling receptor binding enzyme binding protease binding serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity identical protein binding protein homodimerization activity protein dimerization activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity chemorepellent activity receptor ligand activity signaling receptor activator activity aminopeptidase activity	membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization biological process involved in interaction with host vesicle-mediated transport biological process involved in symbiotic interaction membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization biological process involved in interaction with host vesicle-mediated transport biological process involved in symbiotic interaction localization symbiont entry into host cell viral process symbiont entry into host endocytosis involved in viral entry into host cell endocytosis receptor-mediated endocytosis transport of virus endothelial cell migration cell migration cell motility cellular response to stimulus negative regulation of locomotion regulation of cell motility regulation of cellular process response to stimulus negative regulation of biological process negative regulation of chemotaxis taxis regulation of immune system process negative regulation of cell migration chemotaxis regulation of biological process regulation of leukocyte chemotaxis regulation of leukocyte migration response to external stimulus neutrophil migration granulocyte migration leukocyte migration negative regulation of leukocyte migration regulation of response to stimulus regulation of locomotion response to chemical negative regulation of response to external stimulus regulation of neutrophil chemotaxis negative regulation of cell motility regulation of neutrophil migration negative regulation of neutrophil chemotaxis negative regulation of leukocyte chemotaxis regulation of response to external stimulus neutrophil chemotaxis regulation of granulocyte chemotaxis negative regulation of cellular process regulation of cell migration myeloid leukocyte migration locomotion cell chemotaxis negative regulation of response to stimulus negative regulation of granulocyte chemotaxis biological regulation regulation of chemotaxis cellular response to chemical stimulus negative regulation of immune system process immune system process granulocyte chemotaxis negative regulation of neutrophil migration leukocyte chemotaxis peptide hormone processing cellular biosynthetic process regulation of hormone levels cellular metabolic process signaling receptor ligand precursor processing primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process protein maturation biosynthetic process proteolysis protein processing metabolic process amide metabolic process protein metabolic process macromolecule metabolic process regulation of biological quality glucagon processing behavior multicellular organismal process locomotory behavior exploration behavior locomotory exploration behavior cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host T cell activation cell activation lymphocyte activation leukocyte activation cell adhesion response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus psychomotor behavior motor behavior cell-cell adhesion mediated by integrin regulation of cell adhesion mediated by integrin regulation of cell adhesion regulation of cell-cell adhesion mediated by integrin cell-cell adhesion cell adhesion mediated by integrin regulation of cell-cell adhesion behavioral defense response fear response behavioral fear response defense response multicellular organismal response to stress cellular component disassembly negative regulation of extracellular matrix organization extracellular matrix disassembly regulation of cellular component organization negative regulation of cellular component organization extracellular matrix organization negative regulation of extracellular matrix disassembly regulation of extracellular matrix organization regulation of extracellular matrix disassembly extracellular structure organization external encapsulating structure organization regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation positive regulation of leukocyte activation regulation of multicellular organismal process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell adhesion regulation of T cell activation lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process T cell costimulation regulation of lymphocyte activation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell-cell junction intercellular canaliculus cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane cell periphery apical part of cell anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell-cell junction intercellular canaliculus cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface membrane microdomain membrane raft intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle cytoplasm endocytic vesicle leading edge membrane lamellipodium membrane cell projection membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome
E, F, G, H	ADENOSINE DEAMINASE	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines adenosine deaminase activity hydrolase activity catalytic activity deaminase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2'-deoxyadenosine deaminase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation purine ribonucleoside monophosphate biosynthetic process nucleobase-containing compound metabolic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine nucleoside monophosphate metabolic process multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation purine ribonucleoside monophosphate biosynthetic process nucleobase-containing compound metabolic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process nucleoside monophosphate metabolic process phosphorus metabolic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process ribonucleoside monophosphate biosynthetic process purine-containing compound salvage purine nucleobase metabolic process nucleobase biosynthetic process purine nucleobase biosynthetic process hypoxanthine biosynthetic process purine-containing compound metabolic process hypoxanthine metabolic process purine-containing compound biosynthetic process nucleobase metabolic process hypoxanthine salvage purine nucleobase salvage cellular metabolic compound salvage cell adhesion glycosyl compound metabolic process catabolic process purine nucleoside catabolic process carbohydrate derivative metabolic process purine ribonucleoside metabolic process carbohydrate derivative catabolic process adenosine catabolic process glycosyl compound catabolic process purine-containing compound catabolic process nucleoside metabolic process nucleobase-containing compound catabolic process adenosine metabolic process nucleobase-containing small molecule catabolic process nucleoside catabolic process small molecule catabolic process ribonucleoside catabolic process purine nucleoside metabolic process purine ribonucleoside catabolic process ribonucleoside metabolic process cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cell communication negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway regulation of biological process regulation of signaling purinergic nucleotide receptor signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus G protein-coupled purinergic receptor signaling pathway biological regulation negative regulation of signal transduction regulation of adenosine receptor signaling pathway regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway negative regulation of adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway nucleotide metabolic process nucleoside biosynthetic process carbohydrate derivative biosynthetic process glycosyl compound biosynthetic process inosine metabolic process small molecule biosynthetic process purine ribonucleoside biosynthetic process ribonucleoside biosynthetic process nucleobase-containing small molecule biosynthetic process inosine biosynthetic process purine nucleoside biosynthetic process	membrane-bounded organelle vesicle lumen intracellular anatomical structure membrane-enclosed lumen intracellular vesicle cytoplasmic vesicle lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle organelle cytoplasm membrane-bounded organelle vesicle lumen intracellular anatomical structure membrane-enclosed lumen intracellular vesicle cytoplasmic vesicle lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle organelle cytoplasm vesicle cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cytosol anchoring junction cell junction lytic vacuole vacuole lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001375	Peptidase S9, prolyl oligopeptidase, catalytic domain	Domain
A, B, C, D	IPR050278	Serine protease S9B/DPPIV	Family
A, B, C, D	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B, C, D	IPR002471	Peptidase S9, serine active site	Active Site
A, B, C, D	IPR002469	Dipeptidylpeptidase IV, N-terminal domain	Domain
E, F, G, H	IPR001365	Adenosine deaminase domain	Domain
E, F, G, H	IPR032466	Metal-dependent hydrolase	Homologous Superfamily
E, F, G, H	IPR028893	Adenosine deaminase	Family
E, F, G, H	IPR006330	Adenosine/adenine deaminase	Family
E, F, G, H	IPR006650	Adenosine/AMP deaminase active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P27487	rheumatoid arthritis proteinuria type 2 diabetes mellitus malignant glioma Middle East respiratory syndrome ovarian cancer asthma common variable immunodeficiency cystic fibrosis glioblastoma hypoglycemia invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma rheumatoid arthritis proteinuria type 2 diabetes mellitus malignant glioma Middle East respiratory syndrome ovarian cancer asthma common variable immunodeficiency cystic fibrosis glioblastoma hypoglycemia invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma prediabetes syndrome tuberculosis Barrett esophagus coronary artery disease depressive disorder hyperglycemia inborn carbohydrate metabolic disorder kidney disease lung carcinoma Mental Depression obesity disorder cerebrovascular disorder COVID-19 hypertensive disorder interstitial cystitis lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.