Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1wpla_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Bd1wplb_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Cd1wplc_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Dd1wpld_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ed1wple_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Fd1wplf_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Gd1wplg_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Hd1wplh_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Id1wpli_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Jd1wplj_ Alpha and beta proteins (a+b) T-fold Tetrahydrobiopterin biosynthesis enzymes-like GTP cyclohydrolase I GTP cyclohydrolase I Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Kd1wplk_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ld1wpll_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Md1wplm_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Nd1wpln_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Od1wplo_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Pd1wplp_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Qd1wplq_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Rd1wplr_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Sd1wpls_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Td1wplt_ Alpha and beta proteins (a+b) GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP GTP cyclohydrolase I feedback regulatory protein, GFRP Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyGTP cyclohydrolase I 8029414 4001710 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyTetrahydrobiopterin biosynthesis enzymes-like 8041793 3000283 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
PSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
QSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
RSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
SSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)
TSCOP2B SuperfamilyGTP cyclohydrolase I feedback regulatory protein, GFRP 8036999 3000919 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGTP_cyclohydroIe1wplA1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
BGTP_cyclohydroIe1wplB1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
CGTP_cyclohydroIe1wplC1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
DGTP_cyclohydroIe1wplD1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
EGTP_cyclohydroIe1wplE1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
FGTP_cyclohydroIe1wplF1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
GGTP_cyclohydroIe1wplG1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
HGTP_cyclohydroIe1wplH1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
IGTP_cyclohydroIe1wplI1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
JGTP_cyclohydroIe1wplJ1 A: a+b two layersX: T-foldH: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)T: Tetrahydrobiopterin biosynthesis enzymes-likeF: GTP_cyclohydroIECOD (1.6)
KGFRPe1wplK1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
LGFRPe1wplL1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
MGFRPe1wplM1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
NGFRPe1wplN1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
OGFRPe1wplO1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
PGFRPe1wplP1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
QGFRPe1wplQ1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
RGFRPe1wplR1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
SGFRPe1wplS1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)
TGFRPe1wplT1 A: a+b two layersX: Glucose permease domain IIB-likeH: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)T: GTP cyclohydrolase I feedback regulatory protein, GFRPF: GFRPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
A3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
B1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
B3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
C1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
C3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
D1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
D3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
E1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
E3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
F1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
F3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
G1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
G3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
H1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
H3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
I1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
I3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
J1.10.286.10 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I Chain A, domain 1CATH (4.3.0)
J3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domainCATH (4.3.0)
K3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
L3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
M3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
N3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
O3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
P3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
Q3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
R3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
S3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)
T3.30.1410.10 Alpha Beta 2-Layer Sandwich Gtp Cyclohydrolase I Feedback Regulatory Protein Chain: KCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF01227GTP cyclohydrolase I (GTP_cyclohydroI)GTP cyclohydrolase IThis family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.Domain
K, L, M, N, O
PF06399GTP cyclohydrolase I feedback regulatory protein (GFRP) (GFRP)GTP cyclohydrolase I feedback regulatory protein (GFRP)Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I f ...Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP) [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
GTP cyclohydrolase I
K, L, M, N, O
GTP cyclohydrolase I feedback regulatory protein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR018234GTP cyclohydrolase I, conserved siteConserved Site
A, B, C, D, E
IPR020602GTP cyclohydrolase I domainDomain
A, B, C, D, E
IPR043133GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductaseHomologous Superfamily
A, B, C, D, E
IPR043134GTP cyclohydrolase I, N-terminal domainHomologous Superfamily
A, B, C, D, E
IPR001474GTP cyclohydrolase IFamily
K, L, M, N, O
IPR036717GFRP superfamilyHomologous Superfamily
K, L, M, N, O
IPR009112GTP cyclohydrolase I, feedback regulatory proteinFamily