1X6V

The crystal structure of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d1x6vb1	All beta proteins	PUA domain-like	PUA domain-like	ATP sulfurylase N-terminal domain	ATP sulfurylase N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth B]	d1x6vb2	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Nucleotidylyl transferase	ATP sulfurylase catalytic domain	ATP sulfurylase catalytic domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth B]	d1x6vb3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Adenosine-5'phosphosulfate kinase (APS kinase)	Adenosine-5'phosphosulfate kinase (APS kinase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1x6va1	All beta proteins	PUA domain-like	PUA domain-like	ATP sulfurylase N-terminal domain	ATP sulfurylase N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1x6va2	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Nucleotidylyl transferase	ATP sulfurylase catalytic domain	ATP sulfurylase catalytic domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1x6va3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Adenosine-5'phosphosulfate kinase (APS kinase)	Adenosine-5'phosphosulfate kinase (APS kinase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1x6va4	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8018688	3002021	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	Nucleotidylyl transferase	8018692	3001541	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	PUA domain-like	8018694	3001015	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8018688	3002021	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	PUA domain-like	8018694	3001015	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Nucleotidylyl transferase	8018692	3001541	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PUA_2	e1x6vB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA_2	ECOD (1.6)
A [auth B]	APS_kinase_1	e1x6vB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: APS_kinase_1	ECOD (1.6)
A [auth B]	ATP-sulfurylase	e1x6vB3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: ATP-sulfurylase	ECOD (1.6)
B [auth A]	PUA_2	e1x6vA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA_2	ECOD (1.6)
B [auth A]	APS_kinase	e1x6vA6	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: APS_kinase	ECOD (1.6)
B [auth A]	ATP-sulfurylase	e1x6vA3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: ATP-sulfurylase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A [auth B]	3.10.400.10	Alpha Beta	Roll	Sulfate adenylyltransferase	Sulfate adenylyltransferase	CATH (4.3.0)
A [auth B]	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
B [auth A]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B [auth A]	3.10.400.10	Alpha Beta	Roll	Sulfate adenylyltransferase	Sulfate adenylyltransferase	CATH (4.3.0)
B [auth A]	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF14306	PUA-like domain (PUA_2)	PUA-like domain	This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes.	Domain
A [auth B], B [auth A]	PF01747	ATP-sulfurylase (ATP-sulfurylase)	ATP-sulfurylase	This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required ...	This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulphate [2]. ATP sulfurylase catalyses the synthesis of adenosine-phosphosulfate APS from ATP and inorganic sulphate [1].	Domain
A [auth B], B [auth A]	PF01583	Adenylylsulphate kinase (APS_kinase)	Adenylylsulphate kinase	Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding adenylyltransferase activity transferase activity sulfate adenylyltransferase (ATP) activity sulfate adenylyltransferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity kinase activity adenylylsulfate kinase activity phosphotransferase activity, alcohol group as acceptor	developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process cellular biosynthetic process nucleotide biosynthetic process developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process cellular biosynthetic process nucleotide biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process organic acid metabolic process purine ribonucleoside bisphosphate metabolic process purine ribonucleoside bisphosphate biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process purine nucleoside bisphosphate biosynthetic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process cellular metabolic process nucleoside bisphosphate biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process purine ribonucleotide metabolic process purine nucleotide biosynthetic process sulfate assimilation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR015947	PUA-like superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR025980	ATP-sulfurylase PUA-like domain	Domain
A [auth B], B [auth A]	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
A [auth B], B [auth A]	IPR002891	Adenylyl-sulfate kinase	Family
A [auth B], B [auth A]	IPR002650	Sulphate adenylyltransferase	Family
A [auth B], B [auth A]	IPR024951	Sulphate adenylyltransferase catalytic domain	Domain
A [auth B], B [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: O43252	breast cancer lymphoplasmacytic lymphoma ovarian cancer large cell medulloblastoma malignant mesothelioma plasma cell myeloma lung cancer osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.