1XNJ
APS complex of human PAPS synthetase 1
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth B] | SCOP2B Superfamily | Nucleotidylyl transferase | 8018692 | 3001541 | SCOP2B (2022-06-29) |
A [auth B] | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8018688 | 3002021 | SCOP2B (2022-06-29) |
A [auth B] | SCOP2B Superfamily | PUA domain-like | 8018694 | 3001015 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | PUA domain-like | 8018694 | 3001015 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8018688 | 3002021 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | Nucleotidylyl transferase | 8018692 | 3001541 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | PUA_2 | e1xnjB1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PUA domain | F: PUA_2 | ECOD (1.6) |
A [auth B] | APS_kinase_1 | e1xnjB2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: APS_kinase_1 | ECOD (1.6) |
A [auth B] | ATP-sulfurylase | e1xnjB3 | A: a/b three-layered sandwiches | X: HUP domain-like | H: HUP domains (From Topology) | T: HUP domains | F: ATP-sulfurylase | ECOD (1.6) |
B [auth A] | PUA_2 | e1xnjA5 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PUA domain | F: PUA_2 | ECOD (1.6) |
B [auth A] | APS_kinase | e1xnjA6 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: APS_kinase | ECOD (1.6) |
B [auth A] | ATP-sulfurylase | e1xnjA3 | A: a/b three-layered sandwiches | X: HUP domain-like | H: HUP domains (From Topology) | T: HUP domains | F: ATP-sulfurylase | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth B] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
A [auth B] | 3.10.400.10 | Alpha Beta | Roll | Sulfate adenylyltransferase | Sulfate adenylyltransferase | CATH (4.3.0) |
A [auth B] | 3.40.50.620 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | HUPs | CATH (4.3.0) |
B [auth A] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
B [auth A] | 3.10.400.10 | Alpha Beta | Roll | Sulfate adenylyltransferase | Sulfate adenylyltransferase | CATH (4.3.0) |
B [auth A] | 3.40.50.620 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | HUPs | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], B [auth A] | PF14306 | PUA-like domain (PUA_2) | PUA-like domain | This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes. | Domain |
A [auth B], B [auth A] | PF01747 | ATP-sulfurylase (ATP-sulfurylase) | ATP-sulfurylase | This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required ... | Domain |
A [auth B], B [auth A] | PF01583 | Adenylylsulphate kinase (APS_kinase) | Adenylylsulphate kinase | Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth B], B [auth A] | IPR015947 | PUA-like superfamily | Homologous Superfamily |
A [auth B], B [auth A] | IPR025980 | ATP-sulfurylase PUA-like domain | Domain |
A [auth B], B [auth A] | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold | Homologous Superfamily |
A [auth B], B [auth A] | IPR002891 | Adenylyl-sulfate kinase | Family |
A [auth B], B [auth A] | IPR002650 | Sulphate adenylyltransferase | Family |
A [auth B], B [auth A] | IPR024951 | Sulphate adenylyltransferase catalytic domain | Domain |
A [auth B], B [auth A] | IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
A [auth B], B [auth A] | O43252 | :