1Z4R

Human GCN5 Acetyltransferase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1z4ra1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Catalytic domain of GCN5 histone acetyltransferase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1z4ra2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	N-acetyltransferase, NAT	8022760	4001800	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Acyl-CoA N-acyltransferases (Nat)	8035140	3000403	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acetyltransf_10	e1z4rA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	General control of amino acid synthesis protein 5-like 2	histone deacetylase binding protein binding binding enzyme binding catalytic activity, acting on a protein acyltransferase activity histone succinyltransferase activity histone modifying activity peptide N-succinyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity N-acetyltransferase activity histone deacetylase binding protein binding binding enzyme binding catalytic activity, acting on a protein acyltransferase activity histone succinyltransferase activity histone modifying activity peptide N-succinyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity N-acetyltransferase activity histone H3 acetyltransferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity histone H3K9 acetyltransferase activity peptide-lysine-N-acetyltransferase activity protein phosphatase binding phosphatase binding histone H4K12 acetyltransferase activity histone H4 acetyltransferase activity chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity peptide glutaryltransferase activity histone glutaryltransferase activity histone H3K18 acetyltransferase activity transcription factor binding DNA-binding transcription factor binding	developmental process multicellular organismal process regulation of biological process regulation of developmental process biological regulation regulation of stem cell population maintenance regulation of multicellular organismal process maintenance of cell number stem cell population maintenance heart development multicellular organism development anatomical structure development animal organ development circulatory system development developmental process multicellular organismal process regulation of biological process regulation of developmental process biological regulation regulation of stem cell population maintenance regulation of multicellular organismal process maintenance of cell number stem cell population maintenance heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development regulation of multicellular organismal development regulation of bone development skeletal system development bone development cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor regulation of cytoskeleton organization negative regulation of centriole replication regulation of cellular process regulation of cellular component organization microtubule cytoskeleton organization negative regulation of biological process membraneless organelle assembly negative regulation of cell cycle negative regulation of organelle assembly cellular component organization cellular component biogenesis centrosome duplication negative regulation of centrosome cycle cellular component assembly centrosome cycle negative regulation of cellular process cell cycle cellular component organization or biogenesis negative regulation of centrosome duplication regulation of cell cycle regulation of centriole replication centriole replication cell cycle process centriole assembly microtubule organizing center organization organelle assembly negative regulation of cellular component organization regulation of cell cycle process negative regulation of cytoskeleton organization regulation of centrosome cycle regulation of microtubule-based process negative regulation of cell cycle process regulation of cellular component biogenesis regulation of organelle organization organelle organization negative regulation of organelle organization regulation of centrosome duplication regulation of organelle assembly cellular process microtubule-based process cytoskeleton organization embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development embryonic epithelial tube formation tube formation epithelial tube formation tube morphogenesis primary neural tube formation epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure regulation of protein stability regulation of biological quality limb development appendage development RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process fibroblast proliferation cell population proliferation regulation of leukocyte differentiation cellular developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation T cell activation cell differentiation T cell differentiation regulation of immune system process regulation of lymphocyte differentiation hemopoiesis regulation of regulatory T cell differentiation cell activation regulation of T cell activation immune system process regulatory T cell differentiation regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation monosaccharide metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process small molecule metabolic process glucose metabolic process cell division regulation of cell division peptidyl-lysine glutarylation macromolecule modification protein metabolic process protein modification process protein acylation response to nutrient levels negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process positive regulation of cellular component organization cell projection organization regulation of cell projection organization positive regulation of cell projection organization head development brain development central nervous system development midbrain development regulation of small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of gluconeogenesis positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process mitochondrion distribution localization mitochondrion localization organelle localization intracellular distribution of mitochondria regulation of cartilage development connective tissue development cartilage development somitogenesis segmentation anterior/posterior pattern specification pattern specification process regionalization somite development behavior system process learning or memory long-term memory nervous system process cognition memory response to peptide cellular response to tumor necrosis factor response to chemical response to cytokine cellular response to cytokine stimulus response to tumor necrosis factor regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation striated muscle tissue development muscle structure development positive regulation of developmental process positive regulation of cell differentiation positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation muscle tissue development positive regulation of cardiac muscle cell differentiation cardiac muscle tissue development cardiac muscle cell differentiation positive regulation of muscle cell differentiation cardiocyte differentiation regulation of muscle cell differentiation regulation of cardiocyte differentiation positive regulation of multicellular organismal process striated muscle cell differentiation forebrain development telencephalon development regulation of protein modification process regulation of protein metabolic process macromolecule deacylation protein deacetylation regulation of tubulin deacetylation protein deacylation regulation of protein deacetylation tubulin deacetylation regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication negative regulation of small molecule metabolic process negative regulation of gluconeogenesis negative regulation of carbohydrate metabolic process cytokine production regulation of cytokine production positive regulation of gene expression positive regulation of cytokine production regulation of embryonic development response to organic cyclic compound peptidyl-lysine acetylation peptidyl-lysine modification protein acetylation internal peptidyl-lysine acetylation peptidyl-amino acid modification internal protein amino acid acetylation metencephalon development hindbrain development RNA processing RNA splicing regulation of RNA splicing chromatin organization chromatin remodeling	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex catalytic complex peptidase complex intracellular membraneless organelle chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex catalytic complex peptidase complex intracellular membraneless organelle chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle membraneless organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex ATAC complex extracellular region extracellular space centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton mitotic spindle spindle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen RNA polymerase II transcription regulator complex transcription factor TFTC complex RNA polymerase II, holoenzyme nuclear protein-containing complex transcription regulator complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018359	Bromodomain, conserved site	Conserved Site
A	IPR000182	GNAT domain	Domain
A	IPR009464	PCAF, N-terminal	Domain
A	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A	IPR016376	Histone acetyltransferase GCN5/PCAF	Family
A	IPR001487	Bromodomain	Domain
A	IPR037800	Histone acetyltransferase GCN5	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92830	Hashimoto thyroiditis lung adenocarcinoma psoriasis heart disease oligodendroglioma vitiligo hypothyroidism pancreatic ductal adenocarcinoma

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	histone acetyltransferase (GCN5 family) M-CSA #524	p300/CBP-associating factor (PCAF) from Homo sapiens is a histone acetyltransferase. It catalyses the transfer of an acetyl group from acetyl-coenzyme A to the epsilon-amino group of specific lysine residues within histone amino termini. The acetylation of histone plays a crucial role in the transcriptional activation of specific target genes, and in transcriptional regulation. Eukaryotic GCN5 acetyltransferases influence diverse biological processes by acetylating histones and non-histone proteins and regulating chromatin and gene-specific transcription as part of multiprotein complexes.	Defined by 9 residues: PHE:A-74 [auth A-568]PHE:A-79 [auth A-573]GLU:A-81 [auth A-575]ILE:A-82 [auth A-576]VAL:A-83 [auth A-577]CYS:A-85 [auth A-579]LEU:A-117 [auth A-611]ILE:A-148 [auth A-642]TYR:A-151 [auth A-645] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 2.3.1.48 (PDB Primary Data) Search M-CSA Motif + EC 2.3.1.48 EC: 2.3.1 (UniProt) Search M-CSA Motif + EC 2.3.1

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.