Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1ahba_ Alpha and beta proteins (a+b) Ribosome inactivating proteins (RIP) Ribosome inactivating proteins (RIP) Plant cytotoxins alpha-Momorcharin (momordin) balsam pear (Momordica charantia ) [TaxId: 3673 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRibosome inactivating proteins (RIP) 8036972 3001164 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARIPe1ahbA1 A: a+b two layersX: RIP/Polo-box domainH: Ribosome inactivating proteins (RIP) (From Topology)T: Ribosome inactivating proteins (RIP)F: RIPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.420.10 Alpha Beta 3-Layer(aba) Sandwich Ricin (A subunit) domain 1CATH (4.3.0)
A4.10.470.10 Few Secondary Structures Irregular Ricin (A Subunit), domain 2 Ricin (A Subunit), domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00161Ribosome inactivating protein (RIP)Ribosome inactivating protein- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ALPHA-MOMORCHARIN -

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
rRNA N-glycosylase  M-CSA #825

Abrin-A from the seeds of Abrus precatorius is a type II ribosome-inactivating protein (RIP) alongside the homologue Ricin. Like Ricin, it catalyses the endohydrolysis of the N-glycosidic bond at one specific adenosine A4324 on the 28S rRNA. This inhibition of protein biosynthesis is anti-carcinogenic. Abrin-A is composed of two chains which are linked by a disulphide bond. Type I RIPs such as α-Momorcharin however have a single chain, still retaining rRNA-glycosylase activity and share identical catalytic residues to Abrin-A and also excise adenines from a highly conserved loop rRNA.

Defined by 3 residues: ILE:A-71GLU:A-160ARG:A-163
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