Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyThiolase-like 8033515 3000122 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiolase-like 8033512 3000122 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AACP_syn_III_Ce1cgkA2 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ACP_syn_III_CECOD (1.6)
AChal_sti_synt_Ne1cgkA1 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Chal_sti_synt_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00195Chalcone and stilbene synthases, N-terminal domain (Chal_sti_synt_N)Chalcone and stilbene synthases, N-terminal domainThe C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain.Domain
PF02797Chalcone and stilbene synthases, C-terminal domain (Chal_sti_synt_C)Chalcone and stilbene synthases, C-terminal domainThis domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain.Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
naringenin-chalcone synthase  M-CSA #355

Chalcone synthase (CHS) is pivotal for the biosynthesis of flavonoid antimicrobial phytoalexins and anthocyanin pigments in plants. It produces chalcone by condensing one p-coumaroyl- and three malonyl-coenzyme A thioesters into a polyketide reaction intermediate that cyclises without the involvement of specific catalytic residues.

Defined by 4 residues: CYS:A-164PHE:A-215HIS:A-303ASN:A-336
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