Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth R]d1d0gr2 Small proteins TNF receptor-like TNF receptor-like TNF receptor-like Death receptor-5 (dr5) fragment, middle domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth R]d1d0gr1 Small proteins TNF receptor-like TNF receptor-like TNF receptor-like Death receptor-5 (dr5) fragment, N- and C-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth S]d1d0gs2 Small proteins TNF receptor-like TNF receptor-like TNF receptor-like Death receptor-5 (dr5) fragment, middle domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth S]d1d0gs1 Small proteins TNF receptor-like TNF receptor-like TNF receptor-like Death receptor-5 (dr5) fragment, N- and C-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth T]d1d0gt2 Small proteins TNF receptor-like TNF receptor-like TNF receptor-like Death receptor-5 (dr5) fragment, middle domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth T]d1d0gt1 Small proteins TNF receptor-like TNF receptor-like TNF receptor-like Death receptor-5 (dr5) fragment, N- and C-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth A]d1d0ga_ All beta proteins TNF-like TNF-like TNF-like Apoptosis-2 ligand, apo2l/TRAIL human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth B]d1d0gb_ All beta proteins TNF-like TNF-like TNF-like Apoptosis-2 ligand, apo2l/TRAIL human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth D]d1d0gd_ All beta proteins TNF-like TNF-like TNF-like Apoptosis-2 ligand, apo2l/TRAIL human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth R]SCOP2 FamilyTNF receptor-like 8026526 4003512 SCOP2 (2022-06-29)
A [auth R]SCOP2 FamilyTNF receptor-like 8026528 4003512 SCOP2 (2022-06-29)
A [auth R]SCOP2 FamilyTNF receptor-like 8026529 4003512 SCOP2 (2022-06-29)
A [auth R]SCOP2 SuperfamilyTNF receptor-like 8038905 3000971 SCOP2 (2022-06-29)
A [auth R]SCOP2 SuperfamilyTNF receptor-like 8038907 3000971 SCOP2 (2022-06-29)
A [auth R]SCOP2 SuperfamilyTNF receptor-like 8038908 3000971 SCOP2 (2022-06-29)
B [auth S]SCOP2B SuperfamilyTNF receptor-like 8038908 3000971 SCOP2B (2022-06-29)
B [auth S]SCOP2B SuperfamilyTNF receptor-like 8038907 3000971 SCOP2B (2022-06-29)
B [auth S]SCOP2B SuperfamilyTNF receptor-like 8038905 3000971 SCOP2B (2022-06-29)
C [auth T]SCOP2B SuperfamilyTNF receptor-like 8038908 3000971 SCOP2B (2022-06-29)
C [auth T]SCOP2B SuperfamilyTNF receptor-like 8038905 3000971 SCOP2B (2022-06-29)
C [auth T]SCOP2B SuperfamilyTNF receptor-like 8038907 3000971 SCOP2B (2022-06-29)
D [auth A]SCOP2B SuperfamilyTNF-like 8041237 3000061 SCOP2B (2022-06-29)
E [auth B]SCOP2B SuperfamilyTNF-like 8041237 3000061 SCOP2B (2022-06-29)
F [auth D]SCOP2B SuperfamilyTNF-like 8041237 3000061 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth R]TNFR_c6_1e1d0gR2 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: TNFR_c6_1ECOD (1.6)
A [auth R]TNFRSF10_1e1d0gR1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: TNFRSF10_1ECOD (1.6)
A [auth R]UNK_F_TYPEe1d0gR3 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: UNK_F_TYPEECOD (1.6)
B [auth S]TNFR_c6_1e1d0gS2 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: TNFR_c6_1ECOD (1.6)
B [auth S]TNFRSF10_1e1d0gS1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: TNFRSF10_1ECOD (1.6)
B [auth S]UNK_F_TYPEe1d0gS3 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: UNK_F_TYPEECOD (1.6)
C [auth T]TNFR_c6_1e1d0gT2 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: TNFR_c6_1ECOD (1.6)
C [auth T]TNFRSF10_1e1d0gT1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: TNFRSF10_1ECOD (1.6)
C [auth T]UNK_F_TYPEe1d0gT3 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: TNF receptor-likeF: UNK_F_TYPEECOD (1.6)
D [auth A]TNFe1d0gA1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
E [auth B]TNFe1d0gB1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
F [auth D]TNFe1d0gD1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth R]2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A domain 2CATH (4.3.0)
B [auth S]2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A domain 2CATH (4.3.0)
C [auth T]2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A domain 2CATH (4.3.0)
D [auth A]2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
E [auth B]2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
F [auth D]2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth R],
B [auth S],
C [auth T]
PF00020TNFR/NGFR cysteine-rich region (TNFR_c6)TNFR/NGFR cysteine-rich region- Domain
D [auth A],
E [auth B],
F [auth D]
PF00229TNF(Tumour Necrosis Factor) family (TNF)TNF(Tumour Necrosis Factor) family- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth R],
B [auth S],
C [auth T]
DEATH RECEPTOR-5
D [auth A],
E [auth B],
F [auth D]
APOPTOSIS-2 LIGAND

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth R],
B [auth S],
C [auth T]
PharosO14763
D [auth A],
E [auth B],
F [auth D]
PharosP50591