Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1h6va2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, middle domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ad1h6va1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, N- and C-terminal domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ad1h6va3 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain Mammalian thioredoxin reductase RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Bd1h6vb2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, middle domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Bd1h6vb1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, N- and C-terminal domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Bd1h6vb3 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain Mammalian thioredoxin reductase RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Cd1h6vc2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, middle domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Cd1h6vc1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, N- and C-terminal domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Cd1h6vc3 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain Mammalian thioredoxin reductase RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Dd1h6vd2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, middle domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Dd1h6vd1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, N- and C-terminal domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Dd1h6vd3 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain Mammalian thioredoxin reductase RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ed1h6ve2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, middle domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ed1h6ve1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, N- and C-terminal domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ed1h6ve3 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain Mammalian thioredoxin reductase RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Fd1h6vf2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, middle domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Fd1h6vf1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD/NAD-linked reductases, N-terminal and central domains Mammalian thioredoxin reductase, N- and C-terminal domain RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Fd1h6vf3 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain Mammalian thioredoxin reductase RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyGlutathione reductase-like 8056198 4000121 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyThioredoxin reductase-like 8056199 3000050 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyGSR C-terminal domain-like 8056200 3000028 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyThioredoxin reductase-like 8056199 3000050 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyGSR C-terminal domain-like 8056200 3000028 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGSR C-terminal domain-like 8056200 3000028 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThioredoxin reductase-like 8056199 3000050 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThioredoxin reductase-like 8056199 3000050 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyGSR C-terminal domain-like 8056200 3000028 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThioredoxin reductase-like 8056199 3000050 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyGSR C-terminal domain-like 8056200 3000028 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThioredoxin reductase-like 8056199 3000050 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyGSR C-terminal domain-like 8056200 3000028 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APyr_redox_dime1h6vA1 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD/NAD-linked reduatases, dimerisation (C-terminal) domain (From Topology)T: FAD/NAD-linked reduatases, dimerisation (C-terminal) domainF: Pyr_redox_dimECOD (1.6)
APyr_redox_2_1e1h6vA3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2_1ECOD (1.6)
APyr_redox_2e1h6vA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2ECOD (1.6)
BPyr_redox_dime1h6vB1 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD/NAD-linked reduatases, dimerisation (C-terminal) domain (From Topology)T: FAD/NAD-linked reduatases, dimerisation (C-terminal) domainF: Pyr_redox_dimECOD (1.6)
BPyr_redox_2_1e1h6vB3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2_1ECOD (1.6)
BPyr_redox_2e1h6vB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2ECOD (1.6)
CPyr_redox_dime1h6vC1 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD/NAD-linked reduatases, dimerisation (C-terminal) domain (From Topology)T: FAD/NAD-linked reduatases, dimerisation (C-terminal) domainF: Pyr_redox_dimECOD (1.6)
CPyr_redox_2_1e1h6vC3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2_1ECOD (1.6)
CPyr_redox_2e1h6vC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2ECOD (1.6)
DPyr_redox_dime1h6vD1 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD/NAD-linked reduatases, dimerisation (C-terminal) domain (From Topology)T: FAD/NAD-linked reduatases, dimerisation (C-terminal) domainF: Pyr_redox_dimECOD (1.6)
DPyr_redox_2_1e1h6vD3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2_1ECOD (1.6)
DPyr_redox_2e1h6vD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2ECOD (1.6)
EPyr_redox_dime1h6vE1 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD/NAD-linked reduatases, dimerisation (C-terminal) domain (From Topology)T: FAD/NAD-linked reduatases, dimerisation (C-terminal) domainF: Pyr_redox_dimECOD (1.6)
EPyr_redox_2_1e1h6vE3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2_1ECOD (1.6)
EPyr_redox_2e1h6vE2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2ECOD (1.6)
FPyr_redox_dime1h6vF1 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD/NAD-linked reduatases, dimerisation (C-terminal) domain (From Topology)T: FAD/NAD-linked reduatases, dimerisation (C-terminal) domainF: Pyr_redox_dimECOD (1.6)
FPyr_redox_2_1e1h6vF3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2_1ECOD (1.6)
FPyr_redox_2e1h6vF2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: Pyr_redox_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00070Pyridine nucleotide-disulphide oxidoreductase (Pyr_redox)Pyridine nucleotide-disulphide oxidoreductaseThis family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.Domain
A, B, C, D, E
PF00890FAD binding domain (FAD_binding_2)FAD binding domain- Family
A, B, C, D, E
PF02852Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (Pyr_redox_dim)Pyridine nucleotide-disulphide oxidoreductase, dimerisation domainThis family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
THIOREDOXIN REDUCTASE