1HF8

CALM-N N-terminal domain of clathrin assembly lymphoid myeloid leukaemia protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hf8a1	All alpha proteins	Spectrin repeat-like	GAT-like domain	Phosphoinositide-binding clathrin adaptor, domain 2	Clathrin assembly lymphoid myeloid leukaemia protein, Calm	NORWAY RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1hf8a2	All alpha proteins	alpha-alpha superhelix	ENTH/VHS domain	Phosphoinositide-binding clathrin adaptor, N-terminal domain	Clathrin assembly lymphoid myeloid leukaemia protein, Calm	NORWAY RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Phosphoinositide-binding clathrin adaptor, domain 2	8023172	4000581	SCOP2 (2022-06-29)
A	SCOP2 Family	Phosphoinositide-binding clathrin adaptor, N-terminal domain	8023175	4000571	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GAT-like domain	8035552	3001306	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ENTH/VHS domain-like	8035555	3000164	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANTH_C	e1hf8A1	A: alpha bundles	X: Spectrin repeat-like	H: GAT-like domain (From Topology)	T: GAT-like domain	F: ANTH_C	ECOD (1.6)
A	ANTH_N	e1hf8A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANTH_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
A	1.20.58.150	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07651	ANTH domain (ANTH)	ANTH domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CLATHRIN ASSEMBLY PROTEIN SHORT FORM	small GTPase binding protein binding binding enzyme binding GTPase binding SH3 domain binding protein domain specific binding cytoskeletal protein binding tau protein binding identical protein binding clathrin binding clathrin heavy chain binding ion binding phosphatidylinositol-4,5-bisphosphate binding small GTPase binding protein binding binding enzyme binding GTPase binding SH3 domain binding protein domain specific binding cytoskeletal protein binding tau protein binding identical protein binding clathrin binding clathrin heavy chain binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding SNARE binding 1-phosphatidylinositol binding low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein localization regulation of localization cellular localization regulation of biological process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation negative regulation of biological process localization negative regulation of protein localization to cell surface protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization negative regulation of cellular process regulation of protein localization to cell surface cellular process negative regulation of protein localization amyloid precursor protein catabolic process positive regulation of protein metabolic process regulation of protein metabolic process positive regulation of biological process primary metabolic process regulation of amyloid precursor protein catabolic process regulation of macromolecule metabolic process regulation of primary metabolic process positive regulation of metabolic process metabolic process positive regulation of macromolecule metabolic process protein metabolic process macromolecule metabolic process positive regulation of amyloid precursor protein catabolic process amyloid precursor protein metabolic process regulation of metabolic process positive regulation of cellular process import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport regulation of cellular component organization regulation of transport regulation of vesicle-mediated transport cellular component organization cellular component organization or biogenesis regulation of endocytosis multicellular organismal process positive regulation of nervous system development axonogenesis cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization multicellular organismal-level iron ion homeostasis multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis hemopoiesis establishment of organelle localization vesicle budding from membrane synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse vesicle organization synaptic vesicle recycling organelle localization establishment of localization in cell synaptic vesicle budding synaptic vesicle localization synaptic vesicle endocytosis membrane organization vesicle localization establishment of vesicle localization synaptic vesicle budding from presynaptic endocytic zone membrane organelle organization synaptic vesicle transport regulation of synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of protein localization nitrogen compound transport regulation of establishment of protein localization regulation of protein transport protein transport negative regulation of transport negative regulation of endocytosis negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis regulation of synaptic vesicle transport vesicle cargo loading intracellular transport endosomal transport regulation of growth developmental growth regulation of cell morphogenesis positive regulation of developmental growth developmental growth involved in morphogenesis positive regulation of dendrite extension cell growth dendrite extension neuron projection extension regulation of developmental growth developmental cell growth growth regulation of dendrite extension positive regulation of cell growth regulation of cell growth positive regulation of growth presynapse organization regulation of terminal button organization terminal button organization regulation of synapse organization cell junction organization regulation of presynapse organization regulation of synapse structure or activity synapse organization regulation of biological quality negative regulation of protein localization to plasma membrane regulation of protein localization to membrane protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane membrane bending synaptic vesicle clustering positive regulation of transport positive regulation of synaptic vesicle clustering regulation of synaptic vesicle clustering dendrite development dendrite morphogenesis clathrin-dependent endocytosis regulation of cellular component size regulation of vesicle size regulation of anatomical structure size regulation of amide metabolic process regulation of amyloid-beta formation positive regulation of amyloid-beta formation amyloid-beta metabolic process amide metabolic process amyloid-beta formation positive regulation of amide metabolic process clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly behavior system process learning or memory nervous system process cognition positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription amyloid-beta clearance amyloid-beta clearance by transcytosis transcytosis negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process synaptic vesicle maturation developmental maturation cellular response to stimulus positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of Ras protein signal transduction intracellular signaling cassette signal transduction positive regulation of Ras protein signal transduction regulation of signaling Ras protein signal transduction positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of small GTPase mediated signal transduction positive regulation of signaling positive regulation of synaptic vesicle recycling positive regulation of endocytosis positive regulation of synaptic vesicle endocytosis	membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system endosome to plasma membrane transport vesicle intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle secretory vesicle cytoplasm vesicle membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system endosome to plasma membrane transport vesicle intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle secretory vesicle cytoplasm vesicle exocytic vesicle cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane clathrin-coated pit postsynaptic endocytic zone parallel fiber to Purkinje cell synapse excitatory synapse presynapse presynaptic membrane extrinsic component of plasma membrane presynaptic endocytic zone extrinsic component of presynaptic endocytic zone membrane extrinsic component of synaptic membrane presynaptic endocytic zone membrane extrinsic component of presynaptic membrane extrinsic component of membrane Golgi apparatus neurofibrillary tangle inclusion body perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body synaptic vesicle protein-containing complex plasma membrane protein complex membrane protein complex coated membrane clathrin coat membrane coat clathrin coat of coated pit clathrin-coated vesicle coated vesicle cell surface early endosome endosome postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse Schaffer collateral - CA1 synapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008942	ENTH/VHS	Homologous Superfamily
A	IPR011417	AP180 N-terminal homology (ANTH) domain	Domain
A	IPR045192	Clathrin coat assembly protein AP180-like	Family
A	IPR014712	ANTH domain superfamily	Homologous Superfamily
A	IPR013809	ENTH domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.