Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamilyp53-like transcription factors 8040233 3000758 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyE set domains 8054875 3000070 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyE set domains 8054869 3000070 SCOP2B (2022-06-29)
C [auth D]SCOP2 FamilyAnkyrin repeat 8004154 4000366 SCOP2 (2022-06-29)
C [auth D]SCOP2 SuperfamilyAnkyrin repeat 8057711 3000154 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARHD_dimere1iknA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: RHD_dimerECOD (1.6)
ARHD_DNA_binde1iknA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Common fold of diphtheria toxin/transcription factors/cytochrome fF: RHD_DNA_bindECOD (1.6)
B [auth C]RHD_dimere1iknC1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: RHD_dimerECOD (1.6)
C [auth D]Ank_2e1iknD1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Ankyrin repeat (From Topology)T: Ankyrin repeatF: Ank_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF16179Rel homology dimerisation domain (RHD_dimer)Rel homology dimerisation domainThe Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].Domain
PF00554Rel homology DNA-binding domain (RHD_DNA_bind)Rel homology DNA-binding domainProteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immu ...Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF16179) that functions as a dimerisation domain [1-2].
Domain
B [auth C]PF16179Rel homology dimerisation domain (RHD_dimer)Rel homology dimerisation domainThe Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].Domain
C [auth D]PF00023Ankyrin repeat (Ank)Ankyrin repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
PROTEIN (NF-KAPPA-B P65 SUBUNIT)
B [auth C]PROTEIN (NF-KAPPA-B P50D SUBUNIT)
C [auth D]PROTEIN (I-KAPPA-B-ALPHA)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR033926NFkappaB IPT domainDomain
IPR013783Immunoglobulin-like foldHomologous Superfamily
IPR011539Rel homology domain, DNA-binding domainDomain
IPR030495Transcription factor p65, RHD domain, N-terminalDomain
IPR002909IPT domainDomain
IPR030492Rel homology domain, conserved siteConserved Site
IPR014756Immunoglobulin E-setHomologous Superfamily
IPR037059Rel homology domain (RHD), DNA-binding domain superfamilyHomologous Superfamily
IPR008967p53-like transcription factor, DNA-binding domain superfamilyHomologous Superfamily
IPR000451NF-kappa-B/DorsalFamily
IPR032397Rel homology dimerisation domainDomain
B [auth C]IPR030503Nuclear factor NF-kappa-B, p105 subunit, Rel homology domain, N-terminalDomain
B [auth C]IPR002909IPT domainDomain
B [auth C]IPR030492Rel homology domain, conserved siteConserved Site
B [auth C]IPR033926NFkappaB IPT domainDomain
B [auth C]IPR014756Immunoglobulin E-setHomologous Superfamily
B [auth C]IPR002110Ankyrin repeatRepeat
B [auth C]IPR000488Death domainDomain
B [auth C]IPR013783Immunoglobulin-like foldHomologous Superfamily
B [auth C]IPR037059Rel homology domain (RHD), DNA-binding domain superfamilyHomologous Superfamily
B [auth C]IPR036770Ankyrin repeat-containing domain superfamilyHomologous Superfamily
B [auth C]IPR008967p53-like transcription factor, DNA-binding domain superfamilyHomologous Superfamily
B [auth C]IPR011539Rel homology domain, DNA-binding domainDomain
B [auth C]IPR011029Death-like domain superfamilyHomologous Superfamily
B [auth C]IPR000451NF-kappa-B/DorsalFamily
B [auth C]IPR047096Nuclear factor NF-kappa-B p105 subunit, death domainDomain
B [auth C]IPR032397Rel homology dimerisation domainDomain
C [auth D]IPR036770Ankyrin repeat-containing domain superfamilyHomologous Superfamily
C [auth D]IPR051070NF-kappa-B InhibitorFamily
C [auth D]IPR002110Ankyrin repeatRepeat

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C [auth D]PharosP25963