Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1j00a_ Alpha and beta proteins (a/b) Flavodoxin-like SGNH hydrolase TAP-like Thioesterase I, TAP (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilySGNH hydrolase-like 8097992 3001315 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALipase_GDSL_2e1j00A1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: SGNH hydrolase (From Topology)T: SGNH hydrolaseF: Lipase_GDSL_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1110 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold SGNH hydrolaseCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00657GDSL-like Lipase/Acylhydrolase (Lipase_GDSL)GDSL-like Lipase/Acylhydrolase- Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
lysophospholipase  M-CSA #755

Escherichia coli thioesterase I (TAP) is a multifunctional enzyme possessing the activities of thioesterase, esterase, arylesterase, protease and lysophospholipase. This enzyme is also known as protease I and lysophospholipase L1, and is responsible for the degradation of thioester, amide and ester bonds. In particular, TAP catalyses the hydrolytic cleavage/deacylation of fatty acyl-CoA thioesters from fatty acyl-acyl carrier proteins, especially those with long acyl groups. TAP has stereoselectivity for amino acid derivative substrates, and hence is useful for the kinetic resolution of racemic mixtures of industrial chemicals.

Defined by 5 residues: SER:A-10GLY:A-44ASN:A-73ASP:A-154HIS:A-157
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Explore in 3DM-CSA Motif Definition
EC: 3.1.2 (PDB Primary Data)