Annotations: 1L6W

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1l6wd_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1l6wf_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I	d1l6wi_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J	d1l6wj_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1l6wa_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1l6wb_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1l6wc_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1l6we_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1l6wg_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H	d1l6wh_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Decameric fructose-6-phosphate aldolase/transaldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
A	SCOP2 Family	Class I aldolase	8028738	4003216	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aldolase	8041117	3000445	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Aldolase	8041117	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	TAL_FSA	e1l6wD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
F	TAL_FSA	e1l6wF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
I	TAL_FSA	e1l6wI1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
J	TAL_FSA	e1l6wJ1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
A	TAL_FSA	e1l6wA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
B	TAL_FSA	e1l6wB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
C	TAL_FSA	e1l6wC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
E	TAL_FSA	e1l6wE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
G	TAL_FSA	e1l6wG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)
H	TAL_FSA	e1l6wH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TAL_FSA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
F	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
I	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
J	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
E	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
G	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
H	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00923	Transaldolase/Fructose-6-phosphate aldolase (TAL_FSA)	Transaldolase/Fructose-6-phosphate aldolase	Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) found almost ubiquitously in the three domains of life (Archaea, Bacteria, and Eukarya). TAL shares a high degree of structural similarity and sequence identity with fructose-6-p ...	Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) found almost ubiquitously in the three domains of life (Archaea, Bacteria, and Eukarya). TAL shares a high degree of structural similarity and sequence identity with fructose-6-phosphate aldolase (FSA). They both belong to the class I aldolase family[4]. Their protein structures have been revealed[5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Fructose-6-phosphate aldolase 1	fructose 6-phosphate aldolase activity lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity identical protein binding protein binding binding	monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process fructose metabolic process catabolic process ketone metabolic process ketone catabolic process small molecule catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR004731	Transaldolase type 3B/Fructose-6-phosphate aldolase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR023001	Fructose-6-phosphate aldolase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR018225	Transaldolase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR033919	Transaldolase/Fructose-6-phosphate aldolase, archaeal/bacterial	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR001585	Transaldolase/Fructose-6-phosphate aldolase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.