1MVU

SINGLE CHAIN FV OF C219 HEAVY CHAIN V101L MUTANT IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mvua_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain kappa variable domain, VL-kappa	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1mvub_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin heavy chain variable domain, VH	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set	e1mvuA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
B	V-set_8	e1mvuB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	C219 Fv, V101>L	V-KAPPA	Mus musculus (house mouse)	IGKV8-1901, IGKJ501	V-DOMAIN V-KAPPA	IG	FV-HEAVY_KAPPA	IMGT (202446-0)
B	C219 Fv, V101>L	VH	Mus musculus (house mouse)	IGHV14-302, IGHJ101, IGHJ1*02	V-DOMAIN VH	IG	FV-HEAVY_KAPPA	IMGT (202446-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A	Light Chain	IGKV8	Kappa	p-glycoprotein	SAbDab (2024-11-15)
B	Heavy Chain	IGHV14	-	p-glycoprotein	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
B	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ig kappa-chain VJ-region (Light chain)	binding antigen binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process	cellular anatomical structure extracellular region extracellular space blood microparticle IgG immunoglobulin complex protein-containing complex immunoglobulin complex
B	Ig VDJ-region (HEAVY CHAIN)	-	-	-
C [auth P]	P-GLYCOPROTEIN	glycerophospholipid flippase activity lipid transporter activity ATPase-coupled intramembrane lipid transporter activity flippase activity intramembrane lipid transporter activity transporter activity phosphatidylethanolamine flippase activity phospholipid transporter activity ATP-dependent activity xenobiotic transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity glycerophospholipid flippase activity lipid transporter activity ATPase-coupled intramembrane lipid transporter activity flippase activity intramembrane lipid transporter activity transporter activity phosphatidylethanolamine flippase activity phospholipid transporter activity ATP-dependent activity xenobiotic transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ABC-type xenobiotic transporter activity transmembrane transporter activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphatidylcholine transporter activity phosphatidylcholine floppase activity floppase activity sphingolipid floppase activity sphingolipid transporter activity ceramide floppase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity efflux transmembrane transporter activity	multicellular organismal process system process xenobiotic transport across blood-brain barrier xenobiotic transport transport vascular transport establishment of localization localization circulatory system process vascular process in circulatory system transport across blood-brain barrier macromolecule localization lipid localization lipid transport multicellular organismal process system process xenobiotic transport across blood-brain barrier xenobiotic transport transport vascular transport establishment of localization localization circulatory system process vascular process in circulatory system transport across blood-brain barrier macromolecule localization lipid localization lipid transport terpenoid transport isoprenoid transport xenobiotic export from cell response to stimulus xenobiotic detoxification by transmembrane export across the plasma membrane detoxification export from cell export across plasma membrane response to toxic substance transmembrane transport response to chemical cellular process membrane organization phospholipid translocation biological regulation phospholipid transport lipid translocation regulation of membrane lipid distribution cellular component organization regulation of biological quality cellular component organization or biogenesis organophosphate ester transport	cell-cell junction intercellular canaliculus cellular anatomical structure anchoring junction cell junction cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050199	Immunoglobulin Heavy Variable	Family
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR013106	Immunoglobulin V-set domain	Domain
A	IPR003599	Immunoglobulin domain subtype	Domain
A	IPR007110	Immunoglobulin-like domain	Domain
B	IPR003597	Immunoglobulin C1-set	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR013106	Immunoglobulin V-set domain	Domain
B	IPR003599	Immunoglobulin domain subtype	Domain
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR050380	Immune Recognition and Response Modulators	Family
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
C [auth P]	IPR017871	ABC transporter-like, conserved site	Conserved Site
C [auth P]	IPR003439	ABC transporter-like, ATP-binding domain	Domain
C [auth P]	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
C [auth P]	IPR003593	AAA+ ATPase domain	Domain
C [auth P]	IPR011527	ABC transporter type 1, transmembrane domain	Domain
C [auth P]	IPR039421	Type 1 protein exporter	Family
C [auth P]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily