Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1mwra1 Alpha and beta proteins (a+b) Cystatin-like NTF2-like Penicillin binding protein 2a (PBP2A), N-terminal domain Penicillin binding protein 2a (PBP2A), N-terminal domain (Staphylococcus aureus ) [TaxId: 1280 ], SCOPe (2.08)
Ad1mwra2 Alpha and beta proteins (a+b) Penicillin binding protein dimerisation domain Penicillin binding protein dimerisation domain Penicillin binding protein dimerisation domain Penicillin binding protein 2a (PBP2A), middle domain (Staphylococcus aureus ) [TaxId: 1280 ], SCOPe (2.08)
Ad1mwra3 Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase Penicillin binding protein 2a (PBP2A), C-terminal domain (Staphylococcus aureus ) [TaxId: 1280 ], SCOPe (2.08)
Bd1mwrb1 Alpha and beta proteins (a+b) Cystatin-like NTF2-like Penicillin binding protein 2a (PBP2A), N-terminal domain Penicillin binding protein 2a (PBP2A), N-terminal domain (Staphylococcus aureus ) [TaxId: 1280 ], SCOPe (2.08)
Bd1mwrb2 Alpha and beta proteins (a+b) Penicillin binding protein dimerisation domain Penicillin binding protein dimerisation domain Penicillin binding protein dimerisation domain Penicillin binding protein 2a (PBP2A), middle domain (Staphylococcus aureus ) [TaxId: 1280 ], SCOPe (2.08)
Bd1mwrb3 Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase Penicillin binding protein 2a (PBP2A), C-terminal domain (Staphylococcus aureus ) [TaxId: 1280 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNTF2-like 8043169 3000472 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPenicillin binding protein dimerisation domain 8043170 3001420 SCOP2B (2022-06-29)
ASCOP2B Superfamilybeta-lactamase/transpeptidase-like 8043171 3001604 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNTF2-like 8043169 3000472 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPenicillin binding protein dimerisation domain 8043170 3001420 SCOP2B (2022-06-29)
BSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8043171 3001604 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APBP_dimere1mwrA3 A: beta complex topologyX: Penicillin binding protein dimerisation domain (From Topology)H: Penicillin binding protein dimerisation domain (From Topology)T: Penicillin binding protein dimerisation domainF: PBP_dimerECOD (1.6)
ATranspeptidase_1ste1mwrA1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_1stECOD (1.6)
AMecA_Ne1mwrA6 A: a+b two layersX: Cystatin-likeH: NTF2-like (From Topology)T: NTF2-likeF: MecA_NECOD (1.6)
AEUF08385e1mwrA5 A: a+b two layersX: ClpS-likeH: Penicillin binding protein ClpS-like domain (From Topology)T: Penicillin binding protein ClpS-like domainF: EUF08385ECOD (1.6)
ATranspeptidase_2nde1mwrA2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_2ndECOD (1.6)
BPBP_dimere1mwrB3 A: beta complex topologyX: Penicillin binding protein dimerisation domain (From Topology)H: Penicillin binding protein dimerisation domain (From Topology)T: Penicillin binding protein dimerisation domainF: PBP_dimerECOD (1.6)
BTranspeptidase_1ste1mwrB1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_1stECOD (1.6)
BMecA_Ne1mwrB5 A: a+b two layersX: Cystatin-likeH: NTF2-like (From Topology)T: NTF2-likeF: MecA_NECOD (1.6)
BEUF08385e1mwrB4 A: a+b two layersX: ClpS-likeH: Penicillin binding protein ClpS-like domain (From Topology)T: Penicillin binding protein ClpS-like domainF: EUF08385ECOD (1.6)
BTranspeptidase_2nde1mwrB2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_2ndECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B
ARO:3000617mecAA foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B
ARO:3001208methicillin resistant PBP2penamantibiotic target replacementCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF03717Penicillin-binding Protein dimerisation domain (PBP_dimer)Penicillin-binding Protein dimerisation domainThis domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' st ...This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure.
Domain
A, B
PF00905Penicillin binding protein transpeptidase domain (Transpeptidase)Penicillin binding protein transpeptidase domainThe active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.Domain