Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1og1a_ Alpha and beta proteins (a+b) ADP-ribosylation ADP-ribosylation Ecto-ART Eukaryotic mono-ADP-ribosyltransferase ART2.2 RAT (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyADP-ribosylation 8042301 3001208 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AARTe1og1A1 A: a+b complex topologyX: ADP-ribosylation (From Topology)H: ADP-ribosylation (From Topology)T: ADP-ribosylationF: ARTECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.90.176.10 Alpha Beta Alpha-Beta Complex Toxin ADP-ribosyltransferase Chain A, domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01129NAD:arginine ADP-ribosyltransferase (ART)NAD:arginine ADP-ribosyltransferase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
NAD+---protein-arginine ADP-ribosyltransferase  M-CSA #869

Mono-ADP-ribosylation is a post-translational modification of proteins in which the ADP-ribose moiety of NAD is transferred to proteins. This process is responsible for the toxicity of some bacterial toxins (e.g., cholera and pertussis toxins). Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also be active. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly.

Defined by 4 residues: SER:A-147GLU:A-159ARG:A-184GLU:A-189
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