Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1q1aa_ Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain Sir2 family of transcriptional regulators Hst2 baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilySir2 family of transcriptional regulators 8027152 4003387 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyDHS-like NAD/FAD-binding domain 8039531 3001728 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASIR2_1ste1q1aA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: SIR2_1stECOD (1.6)
AKOG2682e1q1aA1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: KOG2682ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (4.3.0)
A3.30.1600.10 Alpha Beta 2-Layer Sandwich SIR2/SIRT2 'Small Domain' SIR2/SIRT2 'Small Domain'CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02146Sir2 family (SIR2)Sir2 family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
HST2 protein
Histone H4

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
ALY Parent Component: LYS

RESIDAA0055

PSI-MOD :  N6-acetyl-L-lysine MOD:00064