Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyAldolase 8035737 3000445 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyAldolase 8035737 3000445 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADHquinase_Ie1qfeA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: DHquinase_IECOD (1.6)
BDHquinase_Ie1qfeB1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: DHquinase_IECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
B3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01487Type I 3-dehydroquinase (DHquinase_I)Type I 3-dehydroquinaseType I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the ...Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Type II 3-dehydroquinase catalyses the trans-dehydration of 3-dehydroshikimate see Pfam:PF01220.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
PROTEIN (3-DEHYDROQUINATE DEHYDRATASE) -

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
3-dehydroquinate dehydratase (type I)  M-CSA #54

3-dehydroquinate dehydratase catalyses the third step in the biosynthesis of chorismate within the Shikimate pathway which synthesises aromatic compounds as well as in the degradative quinate pathway. It is a type I dehydroquinase which catalyses a cis-dehydration of the hexane ring of 3-dehydroquinate via a covalent imine intermediate (unlike the type II dehydroquinase which catalyses a trans-dehydration via an enolate intermediate). Type I dehydroquinases use a Schiff base mechanism. The pathway is essential in microorganisms and plants for the biosynthesis of compounds such as folate, ubiquinone and aromatic amino acids. The absence of this pathway in animals makes it an attractive target for antimicrobial agents.

Defined by 3 residues: GLU:A-86HIS:A-143LYS:A-170
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