Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1qola_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Bd1qolb_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Cd1qolc_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Dd1qold_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Ed1qole_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Fd1qolf_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Gd1qolg_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)
Hd1qolh_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases FMDV leader protease FMDV leader protease (Foot-and-mouth disease virus (strain O1) ) [TaxId: 73482 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyCysteine proteinases 8034060 3001808 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_C28e1qolA1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
BPeptidase_C28e1qolB1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
CPeptidase_C28e1qolC1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
DPeptidase_C28e1qolD1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
EPeptidase_C28e1qolE1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
FPeptidase_C28e1qolF1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
GPeptidase_C28e1qolG1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)
HPeptidase_C28e1qolH1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C28ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
B3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
C3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
D3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
E3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
F3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
G3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)
H3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF05408Foot-and-mouth virus L-proteinase (Peptidase_C28)Foot-and-mouth virus L-proteinase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
PROTEASE (NONSTRUCTURAL PROTEIN P20A)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR015031Capsid protein VP4, PicornavirusDomain
A, B, C, D, E
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
A, B, C, D, E
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
A, B, C, D, E
IPR038765Papain-like cysteine peptidase superfamilyHomologous Superfamily
A, B, C, D, E
IPR008739Peptidase C28, foot-and-mouth virus L-proteinaseDomain
A, B, C, D, E
IPR000199Peptidase C3A/C3B, picornaviralDomain
A, B, C, D, E
IPR001676Picornavirus capsidDomain
A, B, C, D, E
IPR014759Helicase, superfamily 3, single-stranded RNA virusDomain
A, B, C, D, E
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B, C, D, E
IPR029053Viral coat protein subunitHomologous Superfamily
A, B, C, D, E
IPR004080Foot-and-mouth disease virus VP1 coatDomain
A, B, C, D, E
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B, C, D, E
IPR004004Helicase/polymerase/peptidase polyprotein, Calicivirus-typeFamily
A, B, C, D, E
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, B, C, D, E
IPR044067Picornavirales 3C/3C-like protease domainDomain
A, B, C, D, E
IPR033703Picornavirus/Calicivirus coat proteinDomain
A, B, C, D, E
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A, B, C, D, E
IPR007094RNA-directed RNA polymerase, catalytic domainDomain
A, B, C, D, E
IPR000605Helicase, superfamily 3, single-stranded DNA/RNA virusDomain
A, B, C, D, E
IPR037080Capsid protein VP4 superfamily, PicornavirusHomologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
L-peptidase  M-CSA #746

The leader protease of foot-and-mouth disease virus FMDV Lpro is a papain-like protease where, as well as cleaving itself from the nascent viral polyprotein, disables host cell protein synthesis by specific proteolysis of a cellular protein: the eukaryotic initiation factor 4G (eIF4G). Its sole role in viral maturation is to free itself from the polyprotein by cleavage between its own C-terminus and the N-terminus of VP4 at the sequence ArgLys LeuLys-|-GlyAlaGlySer.

Later it plays the role of lysing the host cell protein eukaryotic initiation factor eIF4G at the sequence AlaAsnLeuGly-|-ArgThrThrLeu and other eIF4G sequences. As a result, the domain of eIF4G which binds the cap-binding protein eIF4E is separated from the domain of eIF4G which binds eIF3, so that the infected cell is unable to recruit its own capped mRNA to the 40S ribosome. Substrate specificity is achieved with four acidic residues 163-166, not seen in other papain-like proteases.

Defined by 4 residues: ASN:B-18 [auth B-46]ALA:B-23 [auth B-51]HIS:B-120 [auth B-148]ASP:B-135 [auth B-163]
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