Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRibokinase-like 8032756 3001268 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRibokinase-like 8032756 3001268 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRibokinase-like 8032756 3001268 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyRibokinase-like 8032756 3001268 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APfkBe1rk2A1 A: a/b three-layered sandwichesX: Rossmann-likeH: Ribokinase-like (From Topology)T: Ribokinase-likeF: PfkBECOD (1.6)
BPfkBe1rk2B1 A: a/b three-layered sandwichesX: Rossmann-likeH: Ribokinase-like (From Topology)T: Ribokinase-likeF: PfkBECOD (1.6)
CPfkBe1rk2C1 A: a/b three-layered sandwichesX: Rossmann-likeH: Ribokinase-like (From Topology)T: Ribokinase-likeF: PfkBECOD (1.6)
DPfkBe1rk2D1 A: a/b three-layered sandwichesX: Rossmann-likeH: Ribokinase-like (From Topology)T: Ribokinase-likeF: PfkBECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00294pfkB family carbohydrate kinase (PfkB)pfkB family carbohydrate kinaseThis family includes a variety of carbohydrate and pyrimidine kinases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
RIBOKINASE

InterPro: Protein Family Classification InterPro Database Homepage

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
ribokinase  M-CSA #663

Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. The reaction is the first step in ribose metabolism and acts partly to trap ribose within the cell after uptake. Phosphorylation also prepares the sugar for use in the synthesis of nucleotides, histidine and for entry into the pentose phosphate pathway. Ribokinase is apart of the Ribokinase superfamily (also known as the PfkB family) alongside fructokinase and adenosine kinase which share two conserved motifs at the N and C terminus.

Defined by 4 residues: ALA:A-252ALA:A-253GLY:A-254ASP:A-255
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