This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors [3] ...
This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors [3].
Post translational methylation of release factors on the glutamine residue of a conserved GGQ motif is required for efficient termination of protein synthesis. This methylation is performed by an N5-glutamine methyltransferase called HemK. Release factor 1 and 2 contain a conserved GGQ motif that is thought to play a role in activating or positioning the water molecule involved in hydrolysis at the peptidyl transferase active site.
Defined by 3 residues: PHE:A-112 [auth A-100]ASN:A-209 [auth A-197]PRO:A-210 [auth A-198]