Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)
BSCOP2 FamilyNuclear receptor ligand-binding domain 8031801 4001384 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyNuclear receptor ligand-binding domain 8044179 3001442 SCOP2 (2022-06-29)
DSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8044179 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recepe1xvpA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
CHormone_recepe1xvpC1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
BHormone_recepe1xvpB1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
DHormone_recepe1xvpD1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
C1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
B1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
D1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain
B, D
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Retinoic acid receptor RXR-alpha
B, D
Orphan nuclear receptor NR1I3
E, F, G, H
nuclear receptor coactivator 1 isoform 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
A, C
IPR021780Nuclear/hormone receptor activator site AF-1Domain
A, C
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
A, C
IPR000003Retinoid X receptor/HNF4Family
A, C
IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
A, C
IPR001723Nuclear hormone receptorFamily
A, C
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
A, C
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B, D
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
B, D
IPR050234Nuclear hormone receptor family NR1 subfamilyFamily
B, D
IPR001723Nuclear hormone receptorFamily
B, D
IPR001728Thyroid hormone receptorFamily
B, D
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
B, D
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
B, D
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
E, F, G, H
IPR010011Nuclear receptor coactivator, DUF1518Domain
E, F, G, H
IPR028819Nuclear receptor coactivator 1, basic helix-loop-helixDomain
E, F, G, H
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
E, F, G, H
IPR017426Nuclear receptor coactivatorFamily
E, F, G, H
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
E, F, G, H
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
E, F, G, H
IPR035965PAS domain superfamilyHomologous Superfamily
E, F, G, H
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily
E, F, G, H
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
E, F, G, H
IPR013767PAS foldDomain
E, F, G, H
IPR000014PAS domainDomain
E, F, G, H
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C
PharosP19793
B, D
PharosQ14994
E, F, G, H
PharosQ15788