Annotations: 1Z2O

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	Ins134_P3_kin_C	e1z2oX1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: Ins134_P3_kin_C	ECOD (1.6)
A [auth X]	EUF08596	e1z2oX3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: EUF08596	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	3.40.50.10820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Inositol 1,3,4-trisphosphate 5/6-kinase domain	CATH (4.3.0)
A [auth X]	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
A [auth X]	3.30.1490.220	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF05770	Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain (Ins134_P3_kin)	Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphat ...	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1]. This entry represents the ATP-grasp domain.	Domain
A [auth X]	PF21512	Inositol-tetrakisphosphate 1-kinase, preATP-grasp domain (ITPK1_preATP-grasp)	Inositol-tetrakisphosphate 1-kinase, preATP-grasp domain	Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 which may play a regulatory function. It may al ...	Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 which may play a regulatory function. It may also act as an isomerase. This entry represents the preATP-grasp domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	inositol 1,3,4-trisphosphate 5/6-kinase	inositol tetrakisphosphate kinase activity kinase activity transferase activity inositol phosphate kinase activity catalytic activity inositol-3,4,5,6-tetrakisphosphate 1-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding inositol tetrakisphosphate kinase activity kinase activity transferase activity inositol phosphate kinase activity catalytic activity inositol-3,4,5,6-tetrakisphosphate 1-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding isomerase activity inositol-1,3,4-trisphosphate 5-kinase activity inositol trisphosphate kinase activity inositol-1,3,4-trisphosphate 6-kinase activity	polyol metabolic process organic hydroxy compound metabolic process alcohol metabolic process inositol phosphate metabolic process organophosphate metabolic process phosphate-containing compound metabolic process inositol trisphosphate metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR011761	ATP-grasp fold	Domain
A [auth X]	IPR008656	Inositol-tetrakisphosphate 1-kinase	Family
A [auth X]	IPR040464	Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain	Domain
A [auth X]	IPR048629	Inositol-tetrakisphosphate 1-kinase, preATP-grasp domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.