2A3E

Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2a3ea1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	Type II chitinase	Chitinase 1	(Aspergillus fumigatus ) [TaxId: 746128 ],	SCOPe (2.08)
A	d2a3ea2	Alpha and beta proteins (a+b)	FKBP-like	Chitinase insertion domain	Chitinase insertion domain	Chitinase 1	(Aspergillus fumigatus ) [TaxId: 746128 ],	SCOPe (2.08)
B	d2a3eb1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	Type II chitinase	Chitinase 1	(Aspergillus fumigatus ) [TaxId: 746128 ],	SCOPe (2.08)
B	d2a3eb2	Alpha and beta proteins (a+b)	FKBP-like	Chitinase insertion domain	Chitinase insertion domain	Chitinase 1	(Aspergillus fumigatus ) [TaxId: 746128 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Chitinase insertion domain	8043367	3000666	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8043365	3000313	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8043365	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Trans)glycosidases	8043365	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Chitinase insertion domain	8043367	3000666	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Trans)glycosidases	8043365	3000313	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GH18_chitolectin_chitotriosidase_2	e2a3eA1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: GH18_chitolectin_chitotriosidase_2	ECOD (1.6)
A	Glyco_hydro_18	e2a3eA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_18	ECOD (1.6)
B	GH18_chitolectin_chitotriosidase_2	e2a3eB1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: GH18_chitolectin_chitotriosidase_2	ECOD (1.6)
B	Glyco_hydro_18	e2a3eB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_18	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00704	Glycosyl hydrolases family 18 (Glyco_hydro_18)	Glycosyl hydrolases family 18	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	chitinase	chitin binding binding carbohydrate derivative binding chitinase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process macromolecule metabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process macromolecule metabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate metabolic process polysaccharide metabolic process polysaccharide catabolic process carbohydrate catabolic process primary metabolic process	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011583	Chitinase II/V-like, catalytic domain	Domain
A, B	IPR029070	Chitinase insertion domain superfamily	Homologous Superfamily
A, B	IPR001579	Glycosyl hydrolase family 18, active site	Active Site
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR050314	Glycosyl Hydrolase Family 18	Family
A, B	IPR001223	Glycoside hydrolase family 18, catalytic domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.